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Defining the Severe Paediatric Asthma Endotype
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The primary objective of this project is to extensively characterize the endotypes of pre-schoolers (0 to 6 years) and school-age children (6 to 12 years) with SA using an integrated approach, combining a description of their phenotype (asthma symptoms, atopy, and lung function) associated with histological (airway inflammation and remodelling), immune (innate and adaptive immunity), metabolomics, and microbiota analyses. This goal shall be achieved by an unsupervised in-depth analysis of patients requiring bronchial endoscopy, with bronchial alveolar lavage (BAL) and bronchial biopsy, as part of their clinical assessment.
Official title: Defining the Severe Paediatric Asthma Endotype: an Integrated Approach Combining Phenotypic Analyses Related to Immune, Metabolomics and Microbial Features
Key Details
Gender
All
Age Range
Any - 12 Years
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2021-06-15
Completion Date
2025-04-24
Last Updated
2026-05-06
Healthy Volunteers
No
Conditions
Interventions
Blood collection
Blood collection with samples of 15ml max by subject (case or control) at J0, M6 and M12: * subject less than 5 kg : 1.8 to 4.5 ml max * subject 5 kg to 10 kg : 4.5 to 9 ml max * subject 10 kg to 15 kg : 9 to 13.5 ml * subject 15 kg to 20 kg : 13.5 to 15 ml max
Saliva sample
Saliva sample by subject at J0
Nasal
Nasal brushing by subject at J0
Locations (1)
Name: Hôpital Necker-Enfants Malades
Paris, France