Inclusion Criteria:
1. Age ≥ 18 years，no gender limitation；
2. According to the 2018 iwCLL guidelines ，diagnosed as chronic lymphocytic leukemia or small cell lymphoma;
3. Refractory or recurrent CLL/SLL having previously received at least first-line systemic treatment. First-line treatment is defined as the completion of at least 2 cycles of a standard protocol or clinical trial based on current guidelines. Medical record of disease progression after the last treatment failed or remission. According to the 2018 iwCLL guidelines, there are at least one CLL/SLL indications that require treatment. \[Refractory definition: treatment failure (without PR) or PD \< 6 months after the last chemotherapy); Definition of recurrence: Patients with complete response (CR) or partial response (PR) ≥ 6 months after disease progression (PD)\];
4. ECOG Performance Status scored ≤ 1 （Dose Escalation Stage）or ≤ 2（Dose Expansion Stage）；
5. The expected survival is at least 3 months;
6. Adequate hematologic、renal function parameters；
7. If patient have a high risk of developing TLS, The absolute lymphocyte count was ≥ 25× 109/L and there was a lymph node with a maximum diameter ≥ 5 cm assessed by radiology or there was a node with a maximum diameter ≥ 10 cm assessed by radiology ，patient must deal with TLS according to the protocol；
8. For fertile patients: the patient shall consent to effective contraception during the treatment period and for at least 90 days after the last administration of the study treatment, and to receive contraceptive methods such as double-screen contraception, condoms, oral or injectable contraceptives, and intrauterine devices. Male patients should agree to avoid sperm donation;
9. Patients voluntarily signed informed consent;
Exclusion Criteria:
1. The patient's prior antitumor therapy meets one of the following criteria:
1. Use of other cytotoxic drugs, research drugs or other antitumor drugs within 14 days or 5 half-lives before first receiving study drugs;
2. Major surgery was performed within 4 weeks prior to the first receiving study drug or had not fully recovered from previous surgery；
3. Systemic radiotherapy was performed within 28 days prior to the first dose of the study drug, or non-hematological toxicity has not recovered from previous radiotherapy to NCI-CTCAE (version 5.0) level 0-1;
4. Received anti-tumor monoclonal antibody therapy within 4 weeks before receiving the first study drug;
5. The toxicity of previous antitumor therapy has not recovered (≥ NCI-CTCAE \[version 5.0\] level 2), except for hair loss;
6. Received steroid therapy for antitumor within 7 days before first receiving study drug;
2. Has received allogeneic stem cell transplantation or autologous stem cell transplantation within 6 months prior to first receiving research drug；
3. The biopsy confirmed the transformation to Richter's syndrome；
4. Drug resistance to another bcl-2 family protein inhibitor has occurred (for extend study use only)；
5. Cardiac function and disease meet one of the following conditions:
1. The prolonged QTc interval has clinical significance, or the screening stage QTc interval is \>470ms for women or \>450ms for men；
2. American New York Heart Association (NYHA) grade ≥ 2 congestive Heart failure;
3. Unstable angina, myocardial infarction, or arrhythmia requiring treatment during screening, Left ventricular ejection fraction (LVEF) \<50%; Primary cardiomyopathy (e.g., dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmia-causing right ventricular cardiomyopathy, restricted cardiomyopathy, unformed cardiomyopathy);
4. The investigators determined that the patient's cardiac function can't tolerate to TLS prophylaxis；
6. Patients who have a history of significant renal, neurological, psychiatric, pulmonary, endocrine, metabolic, immunological, cardiovascular or liver diseases that the investigator believes may adversely affect Patients participation in the study；
7. Allergy to the same kind of drugs and excipients used in research；
8. A woman who is pregnant or nursing；
9. Except for adequately treated carcinoma in situ of the cervix, basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin, and previous malignancies that have been controlled and surgically removed or treated with radical treatment, a history of other active malignancies except for CLL/SLL Within 3 years of the start of the study；
10. Difficulty swallowing, or having malabsorption syndrome or other medical conditions that prevent the absorption of drugs through the intestine；
11. Exhibit other clinically significant uncontrolled conditions, including but not limited to:
1. Uncontrollable systemic infections (viruses, bacteria, fungi) include viral Hepatitis B (Hepatitis B surface antibody-positive with DNA exceeding 1000 CPS/mL or 1000 IU/ml, or Hepatitis C Virus (HCV) RNA positive)；
2. An active and uncontrolled autoimmune hemocytopenia lasting 2 weeks or longer, including autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura；
12. Systemic diseases that affect patients adherence to study participation.
