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Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Sponsor: Mirati Therapeutics Inc.
Summary
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
Official title: A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
453
Start Date
2021-02-23
Completion Date
2026-10-30
Last Updated
2026-08-11
Healthy Volunteers
No
Interventions
MRTX849
21 day cycles
Docetaxel
21 day cycles
Locations (380)
Local Institution - 012-898
Cerritos, California, United States
Local Institution - 012-910
Duarte, California, United States
Local Institution - 012-898 D
Glendale, California, United States
Local Institution - 012-910-A
Huntington Beach, California, United States
Local Institution - 012-910-C
Irvine, California, United States
Local Institution - 012-910-B
Long Beach, California, United States
Local Institution - 012-910-F
Long Beach, California, United States
Local Institution - 012-910-D
Newport Beach, California, United States
Local Institution - 012-898 C
Santa Ana, California, United States
Local Institution - 012-858
Santa Rosa, California, United States
Local Institution - 012-910-E
Torrance, California, United States
Local Institution - 012-951-B
Denver, Colorado, United States
Local Institution - 012-951
Lafayette, Colorado, United States
Local Institution - 012-872
Lone Tree, Colorado, United States
Local Institution - 012-951-A
Wheat Ridge, Colorado, United States
Local Institution - 012-562-B
Fleming Island, Florida, United States
Local Institution - 012-968
Fort Lauderdale, Florida, United States
Local Institution - 012-562-D
Jacksonville, Florida, United States
Local Institution - 012-853
Jacksonville, Florida, United States
Local Institution - 012-562-E
Jacksonville, Florida, United States
Local Institution - 012-562-A
Jacksonville, Florida, United States
Local Institution - 012-562-C
Jacksonville, Florida, United States
Local Institution - 012-562-F
Jacksonville, Florida, United States
Local Institution - 012-562-G
Jacksonville, Florida, United States
Local Institution - 012-562
Jacksonville, Florida, United States
Local Institution - 012-825
Miami Beach, Florida, United States
Local Institution - 012-973
Orlando, Florida, United States
Local Institution - 012-877
Pensacola, Florida, United States
Local Institution - 012-839
Plantation, Florida, United States
Local Institution - 012-941
Athens, Georgia, United States
Local Institution - 012-835 - A
Austell, Georgia, United States
Local Institution - 012-835 - B
Carrollton, Georgia, United States
Local Institution - 012-835 - C
Cartersville, Georgia, United States
Local Institution - 012-835 - D
Douglasville, Georgia, United States
Local Institution - 012-835
Marietta, Georgia, United States
Local Institution - 012-917
Chicago, Illinois, United States
Local Institution - 012-972
Chicago, Illinois, United States
Local Institution - 012-972 C
Harvey, Illinois, United States
Local Institution - 012-972 A
New Lenox, Illinois, United States
Local Institution - 012-883
Niles, Illinois, United States
Local Institution - 012-972 B
Orland Park, Illinois, United States
Local Institution - 012-943
Goshen, Indiana, United States
Local Institution - 012-569
Indianapolis, Indiana, United States
Local Institution - 012-569 - B
Lafayette, Indiana, United States
Local Institution - 012-569 - C
Lafayette, Indiana, United States
Local Institution - 012-569 - A
Mooresville, Indiana, United States
Local Institution - 012-782
Munster, Indiana, United States
Local Institution - 012-942-B
Chanute, Kansas, United States
Local Institution - 012-942-C
Dodge City, Kansas, United States
Local Institution - 012-942-D
El Dorado, Kansas, United States
Local Institution - 012-942-E
Independence, Kansas, United States
Local Institution - 012-942-F
Kingman, Kansas, United States
Local Institution - 012-942-G
Liberal, Kansas, United States
Local Institution - 012-942-H
McPherson, Kansas, United States
Local Institution - 012-942-I
Newton, Kansas, United States
Local Institution - 012-942-J
Parsons, Kansas, United States
Local Institution - 012-942-K
Pratt, Kansas, United States
Local Institution - 012-942-L
Salina, Kansas, United States
Local Institution - 012-942-M
Wellington, Kansas, United States
Local Institution - 012-820
Westwood, Kansas, United States
Local Institution - 012-942-A
Wichita, Kansas, United States
Local Institution - 012-942
Wichita, Kansas, United States
Local Institution - 012-942-N
Winfield, Kansas, United States
Local Institution - 012-965
Lexington, Kentucky, United States
Local Institution - 012-911 A
New Orleans, Louisiana, United States
Local Institution - 012-911
New Orleans, Louisiana, United States
Local Institution - 012-954 - A
Kennebunk, Maine, United States
Local Institution - 012-954
Scarborough, Maine, United States
Local Institution - 012-954 - B
Topsham, Maine, United States
Local Institution - 012-856
Frederick, Maryland, United States
Local Institution - 012-974-B
Novi, Michigan, United States
Local Institution - 012-974-C
Novi, Michigan, United States
Local Institution - 012-974-A
Southfield, Michigan, United States
Local Institution - 012-974
Southfield, Michigan, United States
Local Institution - 012-952
Bolivar, Missouri, United States
Local Institution - 012-841 - A
Billings, Montana, United States
Local Institution - 012-841
Billings, Montana, United States
Local Institution - 012-846
Billings, Montana, United States
Local Institution - 012-975
East Brunswick, New Jersey, United States
Local Institution - 012-975 - A
Edison, New Jersey, United States
Local Institution - 012-975 - B
Monroe, New Jersey, United States
Local Institution - 012-975 - C
Somerset, New Jersey, United States
Local Institution - 012-975 - D
Somerville, New Jersey, United States
Local Institution - 012-577
Teaneck, New Jersey, United States
Local Institution - 012-962
Syracuse, New York, United States
Local Institution - 012-849
Cleveland, Ohio, United States
Local Institution - 012-836
Kettering, Ohio, United States
Local Institution - 012-967
Salem, Oregon, United States
Local Institution - 012-960
Providence, Rhode Island, United States
Local Institution - 012-960-A
Providence, Rhode Island, United States
Local Institution - 012-891
Greenville, South Carolina, United States
Local Institution - 012-940
Sioux Falls, South Dakota, United States
Local Institution - 012-888
Arlington, Texas, United States
Local Institution - 012-892
Austin, Texas, United States
Local Institution - 012-999
Irving, Texas, United States
Local Institution - 012-890
Sherman, Texas, United States
Local Institution - 012-976
Salt Lake City, Utah, United States
Local Institution - 012-976-A
Salt Lake City, Utah, United States
Local Institution - 012-976-B
Salt Lake City, Utah, United States
Local Institution - 012-976-C
Salt Lake City, Utah, United States
Local Institution - 012-976-D
Salt Lake City, Utah, United States
Local Institution - 012-976-E
Salt Lake City, Utah, United States
Local Institution - 012-976-F
Salt Lake City, Utah, United States
Local Institution - 012-976-G
Salt Lake City, Utah, United States
Local Institution - 012-976-H
Salt Lake City, Utah, United States
Local Institution - 012-976-I
Salt Lake City, Utah, United States
Local Institution - 012-814 - B
Arlington, Virginia, United States
Local Institution - 012-953
Charlottesville, Virginia, United States
Local Institution - 012-814 - A
Fairfax, Virginia, United States
Local Institution - 012-814
Fairfax, Virginia, United States
Local Institution - 012-814 - C
Gainesville, Virginia, United States
Local Institution - 012-814 - D
Leesburg, Virginia, United States
Local Institution - 012-016
Mackay, Queensland, Australia
Local Institution - 012-005
Bedford Park, Australia
Local Institution - 012-004
Clayton, Australia
Local Institution - 012-014
Douglas, Australia
Local Institution - 012-013
St Leonards, Australia
Local Institution - 012-019
Tweed Heads, Australia
Local Institution - 012-017
Wollongong, Australia
Local Institution - 012-009
Woolloongabba, Australia
Local Institution - 012-142
Klagenfurt, Austria
Local Institution - 012-140
Salzburg, Austria
Local Institution - 012-146
Vienna, Austria
Local Institution - 012-154
Brussels, Belgium
Local Institution - 012-157
Edegem, Belgium
Local Institution - 012-155
Ghent, Belgium
Local Institution - 012-151
Gilly, Belgium
Local Institution - 012-158
Hasselt, Belgium
Local Institution - 012-152
Roeselare, Belgium
Local Institution - 012-153
Ronse, Belgium
Local Institution - 012-150
Yvoir, Belgium
Local Institution - 012-725
Beijing, Beijing Municipality, China
Local Institution - 012-700
Beijing, Beijing Municipality, China
Local Institution - 012-738
Beijing, Beijing Municipality, China
Local Institution - 012-724
Beijing, Beijing Municipality, China
Local Institution - 012-727
Chongqing, Chongqing Municipality, China
Local Institution - 012-726
Chongqing, Chongqing Municipality, China
Local Institution - 012-029
Fuzhou, Fujian, China
Local Institution - 012-732
Xiamen, Fujian, China
Local Institution - 012-712
Guangzhou, Guangdong, China
Local Institution - 012-739
Guangzhou, Guangdong, China
Local Institution - 012-733
Liuzhou, Guangxi, China
Local Institution - 012-028
Harbin, Heilongjiang, China
Local Institution - 012-740
Xinxiang, Henan, China
Local Institution - 012-021
Zhengzhou, Henan, China
Local Institution - 012-730
Zhengzhou, Henan, China
Local Institution - 012-023
Wuhan, Hubei, China
Local Institution - 012-701
Wuhan, Hubei, China
Local Institution - 012-702
Changsha, Hunan, China
Local Institution - 012-735
Nanjing, Jiangsu, China
Local Institution - 012-734
Nanjing, Jiangsu, China
Local Institution - 012-729
Nanjing, Jiangsu, China
Local Institution - 012-728
Xuzhou, Jiangsu, China
Local Institution - 012-706
Nanchang, Jiangxi, China
Local Institution - 012-731
Nanchang, Jiangxi, China
Local Institution - 012-030
Changchun, Jilin, China
Local Institution - 012-709
Shenyang, Liaoning, China
Local Institution - 012-036
Jinan, Shandong, China
Local Institution - 012-737
Linyi, Shandong, China
Local Institution - 012-741
Qingdao, Shandong, China
Local Institution - 012-719
Shanghai, Shanghai Municipality, China
Local Institution - 012-024
Shanghai, Shanghai Municipality, China
Local Institution - 012-025
Shanghai, Shanghai Municipality, China
Local Institution - 012-710
Chengdu, Sichuan, China
Local Institution - 012-721
Chengdu, Sichuan, China
Local Institution - 012-722
Hangzhou, Zhejiang, China
Local Institution - 012-736
Hangzhou, Zhejiang, China
Local Institution - 012-034
Hangzhou, Zhejiang, China
Local Institution - 012-164
Hořovice, Czechia
Local Institution - 012-162
Olomouc, Czechia
Local Institution - 012-163
Prague, Czechia
Local Institution - 012-168
Praha 8 - Liben, Czechia
Local Institution - 012-191-A
Pierre-Bénite, Auvergne-Rhône-Alpes, France
Local Institution - 012-191-B
Lyon, Rhone, France
Local Institution - 012-194
Brest, France
Local Institution - 012-191
Bron, France
Local Institution - 012-193
Caen, France
Local Institution - 012-196
Caen, France
Local Institution - 012-190
Créteil, France
Local Institution - 012-192
Dijon, France
Local Institution - 012-201
Gleizé, France
Local Institution - 012-683
La Tronche, France
Local Institution - 012-665
Lille, France
Local Institution - 012-195
Limoges, France
Local Institution - 012-199
Marseille, France
Local Institution - 012-687
Marseille, France
Local Institution - 012-200
Montpellier, France
Local Institution - 012-666
Mulhouse, France
Local Institution - 012-685
Nice, France
Local Institution - 012-681
Quimper, France
Local Institution - 012-198
Saint-Herblain, France
Local Institution - 012-684
Strasbourg, France
Local Institution - 012-197
Strasbourg, France
Local Institution - 012-209
Tours, France
Local Institution - 012-202
Villejuif, France
Local Institution - 012-219
Bad Berka, Germany
Local Institution - 012-222
Bonn, Germany
Local Institution - 012-221
Cologne, Germany
Local Institution - 012-210
Essen, Germany
Local Institution - 012-214
Gauting, Germany
Local Institution - 012-671
Giessen, Germany
Local Institution - 012-659
Grohansdorf, Germany
Local Institution - 012-215
Halle, Germany
Local Institution - 012-225
Jena, Germany
Local Institution - 012-213
Kassel, Germany
Local Institution - 012-224
Löwenstein, Germany
Local Institution - 012-216
Lübeck, Germany
Local Institution - 012-220
München, Germany
Local Institution - 012-672
Offenbach, Germany
Local Institution - 012-212
Oldenburg, Germany
Local Institution - 012-502
Athens, Attica, Greece
Local Institution - 012-236
Athens, Greece
University General Hospital of Heraklion (PAGNI)
Heraklion, Greece
Local Institution - 012-235
Larissa, Greece
Local Institution - 012-237
Nea Kifissia, Greece
Local Institution - 012-234
Piraeus, Greece
Local Institution - 012-239
Piraeus, Greece
Local Institution - 012-504
Thessaloniki, Greece
Local Institution - 012-230
Thessaloniki, Greece
Local Institution - 012-500
Thessaloniki, Greece
Local Institution - 012-503
Volos, Greece
Local Institution - 012-048
Central, Hong Kong
Local Institution - 012-043
Hong Kong, Hong Kong
Local Institution - 012-040
Kowloon, Hong Kong
Local Institution - 012-242
Budapest, Hungary
Local Institution - 012-244
Budapest, Hungary
Local Institution - 012-241
Budapest, Hungary
Local Institution - 012-243
Gyöngyös, Hungary
Local Institution - 012-763
Gyula, Hungary
Local Institution - 012-759
Székesfehérvár, Hungary
Local Institution - 012-240
Törökbálint, Hungary
Local Institution - 012-255
Tallaght, Dublin, Ireland
Local Institution - 012-250
Dublin, Ireland
Local Institution - 012-252
Dublin, Ireland
Local Institution - 012-259
Dublin, Ireland
Local Institution - 012-257
Galway, Ireland
Local Institution - 012-258
Limerick, Ireland
Local Institution - 012-276
Alessandria, Italy
Local Institution - 012-292
Avellino, Italy
Local Institution - 012-274
Aviano, Italy
Local Institution - 012-275
Bari, Italy
Local Institution - 012-765
Brescia, Italy
Local Institution - 012-286
Candiolo, Italy
Local Institution - 012-284
Catania, Italy
Local Institution - 012-282
Catania, Italy
Local Institution - 012-762
Florence, Italy
Local Institution - 012-273
Genova, Italy
Local Institution - 012-285
Genova, Italy
Local Institution - 012-279
Lecce, Italy
Local Institution - 012-270
Meldola, Italy
Local Institution - 012-296
Milan, Italy
Local Institution - 012-278
Milan, Italy
Local Institution - 012-283
Milan, Italy
Local Institution - 012-271
Naples, Italy
Local Institution - 012-277
Naples, Italy
Local Institution - 012-770
Novara, Italy
Local Institution - 012-272
Parma, Italy
Local Institution - 012-281
Perugia, Italy
Local Institution - 012-766
Pesaro, Italy
Local Institution - 012-767
Ravenna, Italy
Local Institution - 012-295
Roma, Italy
Local Institution - 012-758
Verona, Italy
Local Institution - 012-306
Amsterdam, Netherlands
Local Institution - 012-309
Breda, Netherlands
Local Institution - 012-300
Maastricht, Netherlands
Local Institution - 012-630
Nijmegen, Netherlands
Local Institution - 012-308
The Hague, Netherlands
Local Institution - 012-307
Utrecht, Netherlands
Local Institution - 012-631
Utrecht, Netherlands
Local Institution - 012-757
Lodz, Poland
Local Institution - 012-321
Lublin, Poland
Local Institution - 012-760
Lublin, Poland
Local Institution - 012-325
Otwock, Poland
Local Institution - 012-320
Rzeszów, Poland
Local Institution - 012-324
Skorzewo, Poland
Local Institution - 012-329
Torun, Poland
Local Institution - 012-322
Warsaw, Poland
Local Institution - 012-774
Warsaw, Poland
Local Institution - 012-644
Almada, Portugal
Local Institution - 012-332
Braga, Portugal
Local Institution - 012-330
Coimbra, Portugal
Local Institution - 012-645
Coimbra, Portugal
Local Institution - 012-333
Guimarães, Portugal
Local Institution - 012-642
Lisbon, Portugal
Local Institution - 012-338-A
Lisbon, Portugal
Local Institution - 012-337
Lisbon, Portugal
Local Institution - 012-338
Lisbon, Portugal
Local Institution - 012-647
Loures, Portugal
Local Institution - 012-334
Porto, Portugal
Local Institution - 012-331
Porto, Portugal
Local Institution - 012-339
Porto, Portugal
Local Institution - 012-641
Santa Maria da Feira, Portugal
Local Institution - 012-646
Setúbal, Portugal
Local Institution - 012-335
Vila Nova de Gaia, Portugal
Local Institution - 012-903
San Juan, PR, Puerto Rico
Local Institution - 012-900
San Juan, PR, Puerto Rico
Local Institution - 012-901
San Juan, Puerto Rico
Local Institution - 012-347
Baia Mare, Romania
Local Institution - 012-349
Brasov, Romania
Local Institution - 012-341
Bucharest, Romania
Local Institution - 012-342
Bucharest, Romania
Local Institution - 012-344
Cluj-Napoca, Romania
Local Institution - 012-340
Cluj-Napoca, Romania
Local Institution - 012-514
Craiova, Romania
Local Institution - 012-343
Craiova, Romania
Local Institution - 012-513
Iași, Romania
Local Institution - 012-519
Ovidiu, Romania
Local Institution - 012-515
Timișoara, Romania
Local Institution - 012-345
Timișoara, Romania
Local Institution - 012-352
Chelyabinsk, Russia
Local Institution - 012-351
Izhevsk, Russia
Local Institution - 012-362
Kislino Village, Russia
Local Institution - 012-353
Moscow, Russia
Local Institution - 012-368
Moscow, Russia
Local Institution - 012-359
Nizhny Novgorod, Russia
Local Institution - 012-356
Novosibirsk, Russia
Local Institution - 012-350
Omsk, Russia
Local Institution - 012-355
Saint Petersburg, Russia
Local Institution - 012-358
Saint Petersburg, Russia
Local Institution - 012-354
Saint Petersburg, Russia
Local Institution - 012-093
Singapore, Singapore
Local Institution - 012-095
Singapore, Singapore
Local Institution - 012-092
Singapore, Singapore
Local Institution - 012-091
Singapore, Singapore
Local Institution - 012-094
Singapore, Singapore
Local Institution - 012-111
Busan, South Korea
Local Institution - 012-522
Busan, South Korea
Local Institution - 012-101
Busan, South Korea
Local Institution - 012-113
Cheongju-si, South Korea
Local Institution - 012-110
Daegu, South Korea
Local Institution - 012-523
Daegu, South Korea
Local Institution - 012-100
Hwasun-gun, South Korea
Local Institution - 012-103
Incheon, South Korea
Local Institution - 012-102
Junggu, South Korea
Local Institution - 012-520
Seongnam-si, South Korea
Local Institution - 012-112
Seongnam-si, South Korea
Local Institution - 012-105
Seoul, South Korea
Local Institution - 012-118
Seoul, South Korea
Local Institution - 012-106
Seoul, South Korea
Local Institution - 012-104
Seoul, South Korea
Local Institution - 012-109
Seoul, South Korea
Local Institution - 012-521
Suwon, South Korea
Local Institution - 012-107
Suwon, South Korea
Local Institution - 012-611A
Pamplona, Navarre, Spain
Local Institution - 012-613
A Coruña, Spain
Local Institution - 012-769
Alicante, Spain
Local Institution - 012-610
Badalona, Spain
Local Institution - 012-776
Barakaldo, Spain
Local Institution - 012-761
Barcelona, Spain
Local Institution - 012-614
Barcelona, Spain
Local Institution - 012-612
Barcelona, Spain
Local Institution - 012-600
Barcelona, Spain
Local Institution - 012-621
Córdoba, Spain
Local Institution - 012-764
Girona, Spain
Local Institution - 012-616
Granada, Spain
Local Institution - 012-628
Las Palmas de Gran Canaria, Spain
Local Institution - 012-775
León, Spain
Local Institution - 012-615
Lugo, Spain
Local Institution - 012-607
Madrid, Spain
Local Institution - 012-611
Madrid, Spain
Local Institution - 012-606
Madrid, Spain
Local Institution - 012-601
Madrid, Spain
Local Institution - 012-609
Madrid, Spain
Local Institution - 012-617
Madrid, Spain
Local Institution - 012-626
Majadahonda, Spain
Local Institution - 012-608
Málaga, Spain
Local Institution - 012-602
Palma de Mallorca, Spain
Local Institution - 012-604
Santander, Spain
Local Institution - 012-629
Seville, Spain
Local Institution - 012-625
Valencia, Spain
Local Institution - 012-605
Valencia, Spain
Local Institution - 012-603
Zaragoza, Spain
Local Institution - 012-390
Basel, Switzerland
Local Institution - 012-391
Thun, Switzerland
Local Institution - 012-392
Winterthur, Switzerland
Local Institution - 012-401
Birmingham, United Kingdom
Local Institution - 012-415
Edinburgh, United Kingdom
Local Institution - 012-400
Glasgow, United Kingdom
Local Institution - 012-408
Leicester, United Kingdom
Local Institution - 012-407
Manchester, United Kingdom