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Microbiome in Cancer Patients With High Dose Chemotherapy With Stem Cell Transplantation
Sponsor: National Cancer Institute, Slovakia
Summary
Numerous in vitro and animal studies as well as growing number of clinical studies support the important role of microbiome in carcinogenesis and cancer treatment. Detection of changes in patients´ microbiome following hematopoietic cell transplantation/CAR-T cell therapy and correlations with adverse transplant outcomes, mainly infectious complications, acute and chronic GvHD, disease recurrence etc. could serve as predictive markers of immune recovery and treatment response.
Official title: Microbiome in Cancer Patients Undergoing High Dose Chemotherapy With Stem Cell Transplantation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-03-01
Completion Date
2026-12
Last Updated
2025-05-29
Healthy Volunteers
No
Conditions
Interventions
Blood, urine and stool sampling
Sampling of blood and urine for miR and chemokine detection. Sampling of stool for for microbiome studies.
Locations (1)
National Cancer Institute
Bratislava, Slovakia, Slovakia