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Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)
Sponsor: Nanjing Medical University
Summary
Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might benefit from statin treatment.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2021-01-01
Completion Date
2024-12-31
Last Updated
2024-12-13
Healthy Volunteers
No
Conditions
Interventions
Rosuvastatin 10mg
Rosuvastatin 10mg is taken by oral or nasal feeding every day at ang time.
Locations (5)
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
The first affiliated hospital of nanjing medical university
Nanjing, Jiangsu, China
Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Beijing Anzhen Hospital
Beijing, China