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RECRUITING
NCT04701671

Project THINK: Trajectories of Health, Ingestive Behaviors, and Neurocognition in Kids

Sponsor: University of Pittsburgh

View on ClinicalTrials.gov

Summary

Overweight/obesity and loss of control eating (characterized by the sense that one cannot control what or how much one is eating) are prevalent among children and adolescents, and both are associated with serious medical and psychosocial health complications. Although our recently published data suggest that youth with these conditions may have relative deficits in neurocognitive functioning, particularly working memory, understanding of how these processes and their neural correlates are related to change and stability in eating and weight-related outcomes over time is limited, thereby impeding development of targeted, optimally timed interventions. The present study aims to assess prospective associations between general and food-specific executive functioning and underlying neural substrates, and eating and weight outcomes among children at varying levels of risk overweight/obesity and eating disorders, which will help guide research efforts towards the development of effective prevention and intervention strategies.

Official title: Executive Functioning, Weight Trajectories, and Loss of Control Eating in Children With Overweight/Obesity: A Prospective Study

Key Details

Gender

All

Age Range

9 Years - 12 Years

Study Type

OBSERVATIONAL

Enrollment

180

Start Date

2020-12-10

Completion Date

2028-05-09

Last Updated

2025-12-10

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Observational (not including MRI scanning)

Observational data will be obtained through self-report measures, parental report measures, cognitive assessments, and a semi-structured interview.

BEHAVIORAL

Observational (including MRI scanning)

Observational data will be obtained through self-report measures, parental report measures, cognitive assessments, fMRI imaging, and a semi-structured interview.

Locations (2)

University of PIttsburgh

Pittsburgh, Pennsylvania, United States

Weight Control & Diabetes Research Center

Providence, Rhode Island, United States