Clinical Research Directory

Inclusion Criteria: * Age ≥18 years old; * Admission to a critical care unit/intensive care unit (ICU) for \> 24 hours; * Receiving vasoactive therapy AND/OR undergoing mechanical ventilation (including non-invasive mechanical ventilation (NIMV)); * Immediate initiation of RRT for management of AKI is planned OR additional RRT sessions are imminently planned for patients who already received RRT during their ICU admission; Exclusion Criteria: * Initiation of RRT for reasons other than AKI (e.g. drug intoxication, hypothermia) ; * Known pre-hospitalization end-stage kidney disease; * Kidney transplant within the past 365 days; * Presence or clinical suspicion of renal obstruction, rapidly progressive glomerulonephritis, vasculitis, thrombotic microangiopathy or acute interstitial nephritis; * Advanced cirrhosis (Child Pugh class C \[score 10-15\]), spontaneous bacterial peritonitis or hepatorenal syndrome; * Acute peritoneal dialysis used as the initial RRT modality; * Contraindications to albumin: 1. Admitted with traumatic brain injury 2. Increased intra-cranial pressure in those with intra-cranial pressure monitoring 3. Prior history of anaphylaxis to intravenous albumin 4. Contraindication or known objection to albumin/blood product transfusions * Already received 2 or more RRT sessions during ICU admission. * Limitations of medical therapy precluding RRT/mechanical ventilation/vasoactive medications or plan to transition to palliation