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Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Cure
Sponsor: University of Maryland, Baltimore
Summary
The study will be an open-labelled randomized clinical trial to determine therapeutic efficacy. Note that this will not be an Investigational New Drug application, as only World Health Organization (WHO)-approved drugs will be used at dosage and for conditions approved.
Key Details
Gender
All
Age Range
15 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2021-04-15
Completion Date
2024-10-01
Last Updated
2026-06-03
Healthy Volunteers
No
Conditions
Interventions
Primaquine
After treatment of the blood stage infection, enrolled participants will receive either no primaquine, a low dose of primaquine or a high dose of primaquine against liver parasites
Artesunate
All enrolled participants will receive a 7-day treatment of artesunate ((2 mg/kg/day) to clear blood-stage parasites
Locations (1)
Institut Pasteur du Cambodge
Phnom Penh, Cambodia