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RECRUITING
NCT04706988

Relationship of Airway Microbiota, Endotype and Phenotype in Adult Asthma

Sponsor: Chinese University of Hong Kong

View on ClinicalTrials.gov

Summary

Increasing evidence supports that the respiratory microbiota, including viral and bacterial microorganisms, play important roles in respiratory health and disease. Microbial patterns in airways may induce distinctive endotypes of asthma. Previous studies suggest host-microbiota interactions in children may account for the heterogeneity of endotypes and clinical presentations. However, information on such relationship is limited in adults. Furthermore, how the upper airway microbiome is related to asthma endotype and phenotype is not well understood. Knowledge of microbiota in the airway allows exploration of therapeutic manipulation of the microbiome and targeting the development of asthma prevention strategies and the optimization of asthma treatment.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

140

Start Date

2021-06-22

Completion Date

2027-12-31

Last Updated

2026-03-19

Healthy Volunteers

No

Conditions

Interventions

OTHER

Treatment of asthma according to GINA guideline

Pharmacological treatment depending on level of control of asthma

Locations (1)

Prince of Wales Hospital

Shatin, Hong Kong