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Trifecta-Heart cfDNA-MMDx Study
Sponsor: University of Alberta
Summary
Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood transplant recipient and the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from heart transplants.
Official title: Trifecta-Heart cfDNA-MMDX Study: Comparing the DD-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2021-06-01
Completion Date
2027-07
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Interventions
MMDx diagnostic test
Microarray test of gene expression in heart biopsies
Prospera
Donor derived cell-free DNA in patient blood
HLA antibody
Centralized measurement of HLA antibodies in patient blood
Locations (12)
Baptist Health Institute for Research and Innovation
Little Rock, Arkansas, United States
Tampa General Hospital, 409 Bayshore Blvd.
Tampa, Florida, United States
Columbia University Medical Center, Columbia Interventional Cardiovascular Care
West New York, New Jersey, United States
Montefiore Medical Center, 3319 Rochambeau Avenue, 2nd FL
The Bronx, New York, United States
Annette C. and Harold C. Simmons Transplant Institute, BaylorScott&White Research Institute
Dallas, Texas, United States
Cardiovascular Medicine, University of Utah Health
Salt Lake City, Utah, United States
Cardiac Transplantation Laboratory, The Victor Chang Cardiac Research Institute
Darlinghurst, Australia
Division of Cardiology, University of Alberta
Edmonton, Alberta, Canada
Institute for Clinical and Experimental Medicine - IKEM Videnska 1958/9
Prague, Czechia
Heart Failure and Heart Transplant Unit, University of Bologna
Bologna, Italy
Silesian Center for Heart Diseases (Ś!ąskie Centrum Chorób Serca w Zabrzu
Zabrze, Poland
Advanced Heart Failure Transplant Unit
A Coruña, Spain