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Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
Sponsor: Stanford University
Summary
The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resistance, and how it is related. This study is needed to confirm whether conclusions based on studies of visceral adipose tissue in mice are indeed applicable to humans. We also want to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals.
Key Details
Gender
All
Age Range
30 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2017-08-01
Completion Date
2025-08
Last Updated
2024-12-04
Healthy Volunteers
Yes
Locations (1)
Stanford University
Stanford, California, United States