Clinical Research Directory

Inclusion Criteria: * Chest pain in patients with clinically suspected or confirmed ischemic heart disease * Clinical indication for non-acute coronary evaluation * Status of coronary revascularization 1. With previous coronary revascularization - all patients 2. Without previous coronary revascularization 1. Age≥65 years - all patients with chest pain 2. Age\>50 - \<65 years - typical angina pectoris and at least one cardiovascular risk factor and/or previous myocardial infarction * Typical angina requiring all 3 criteria present: a) constrictive discomfort in the front of the chest or in the neck, jaw, shoulder or arm, b) precipitated by physical exertion c) relieved by rest or nitrates within 5 min. * Cardiovascular risk factors: hypertension, diabetes, hypercholesterolemia, current smoking, family history of ischemic heart disease, previous stroke, peripheral artery disease Exclusion Criteria: * Persistent chest pain and signs of ongoing acute myocardial ischemia requiring acute coronary intervention * Hospitalization and discharge with the confirmed diagnosis acute coronary syndrome (STEMI or NSTEMI) within the last 6 months * Severe valvular heart disease as primary diagnosis and/or in potential need of percutaneous or surgical valve treatment * Known severe heart failure (LVEF less than 35%) * Language, cultural or mental factors preventing the patient from understanding the informed consent form * Known atrial fibrillation * Known renal impairment (estimated Glomerular Filtration Rate below \<30 ml/min) * Known x-ray contrast allergy * Known intolerance to adenosine infusion