Clinical Research Directory

Inclusion Criteria: 1. All race/ethnicity categories, English speaking, men and women 2. Patient presents with current (within 30 days) Rutherford Class 4, 5, or 6 3. Age ≥18 years 4. Supported by any of the following diagnostic evidence: * Rutherford Classification 4 or ischemic rest pain and/or resting ankle pressure \<50mmHg, flat or barely pulsatile ankle or metatarsal PVR or toe pressure \<40mmHg * Rutherford Classification 5 or minor tissue loss; non-healing ulcer, focal gangrene with diffuse pedal ischemia resting ankle pressure \<50mmHg ankle or metatarsal PVR flat or barely pulsatile or toe pressure \<40mmHg * Rutherford Classification 6 or major tissue loss: extending above transmetatarsal level, functional foot no longer salvageable, resting ankle pressure \<50mmHg ankle or metatarsal PVR flat or barely pulsatile or toe pressure \<40mmHg * CLI related ICD 10 code (reason for admission or indication for procedure) * SPP \< 50 mmHg * TCPO2 \< 50 mmHg * Angiographic evidence no straight line to foot or greater than 70% stenosis in all 3 lower extremity arteries (AT, PT, peroneal) * ABI\* ≤ 0.90 * non-compressible ABI ≥ 1.40 AND TBI ≤ 0.70 * TBI\* ≤ 0.70 Exclusion Criteria: 1. Acute limb ischemia 2. Unable to provide written informed consent 3. Currently a prisoner (identified at time of enrollment)