Clinical Research Directory

Inclusion Criteria: * Participant must be ≥12 to less than 18 years of age at the time of signing the informed consent/assent according to local regulation * Participant has had a diagnosis of moderate to severe plaque psoriasis (PSO) for at least 3 months prior to the Screening Visit and: 1. Body surface area (BSA) affected by PSO ≥10% 2. Investigator's Global Assessment (IGA) score ≥3 (on a scale from 0 to 4) 3. Psoriasis Area and Severity Index (PASI) score ≥12 OR 4. PASI score ≥10 plus at least 1 of the following: i. Clinically relevant facial involvement ii. Clinically relevant genital involvement iii. Clinically relevant hand and foot involvement * Participant must be candidate for systemic PSO therapy and/or photo/chemotherapy * Body weight ≥30 kg and body mass index for age percentile of ≥5 at Baseline * Male or female A female participant will be eligible to participate if she is not pregnant, not breastfeeding, and a woman of childbearing potential (WOCBP) agrees to follow the contraceptive guidance * Capable of giving/having parent(s) or legal representative provide signed informed consent/assent (where appropriate) Exclusion Criteria: * Participant has a presence of guttate, inverse, pustular, or erythrodermic PSO or other dermatological condition that may impact the clinical assessment of PSO * Participant has a history of inflammatory bowel disease (IBD) or symptoms suggestive of IBD * History of active tuberculosis unless successfully treated, latent TB unless prophylactically treated * Participant has an active infection or history of infections (such as serious infection, chronic infections, opportunistic infections, unusually severe infections) * Participant has laboratory abnormalities at Screening * Participant has experienced primary failure to one or more interleukin-17 (IL-17) biologic response modifier OR primary failure to more than 1 biologic response modifier other than an IL-17 biologic response modifier * Presence of active suicidal ideation, or positive suicide behavior * Participant has been diagnosed with severe depression in the past 6 months