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CHronic Nonbacterial Osteomyelitis International Registry
Sponsor: Seattle Children's Hospital
Summary
The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease and the responses of patients to different clinical managements over 10 years.
Official title: CHronic Nonbacterial Osteomyelitis International Registry (CHOIR)
Key Details
Gender
All
Age Range
Any - 21 Years
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2018-08-01
Completion Date
2050-08
Last Updated
2024-07-30
Healthy Volunteers
No
Interventions
Methotrexate
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Sulfasalazine
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Leflunomide
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Pamidronate
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Zoledronic acid
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Etanercept
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Adalimumab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Certolizumab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Infliximab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Golimumab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
NSAID
first-line treatment
Locations (1)
Seattle Children's Hospital
Seattle, Washington, United States