Clinical Research Directory

Inclusion Criteria: * Adult (≥ 18 years old) smokers (at least 5 TC per day for at least 12 months) * Motivated to quit smoking as evidenced by signing the informed consent form at trial enrolment specifying that a target quit date will be set * Exhaled CO ≥ 10 ppm or saliva cotinine of \> 30 ng/ml (in case of borderline CO measurement of 6-10 ppm) at screening * Willing to participate in the trial even if allocated to the control group * Ability to communicate well with the investigator and to understand and comply with the requirements of the study * Signed informed consent form Exclusion Criteria: * Known hypersensitivity/allergy to a content of the e-liquid * Pregnancy or breast feeding * Intention to become pregnant during the course of the study * Current regular use of EC or tobacco heating systems * Use of NRT, varenicline, or bupropion in the month prior to the screening visit * People who smoke tobacco combined with marijuana and do not currently want to quit marijuana use * Participation in an interventional trial within 30 days prior to the screening visit * Legal incapacity or limited legal capacity at screening * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol