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Improving Sleep After TKA Using Mirtazapine and Quetiapine
Sponsor: St. Anna Ziekenhuis, Geldrop, Netherlands
Summary
Use of mirtazapine and quetiapine for improvement of sleep quality after TKA
Official title: Mirtazapine and Quetiapine as Treatment for Postoperative Sleep Disturbance After Fast-track Knee Replacement
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
165
Start Date
2024-01-01
Completion Date
2027-01-01
Last Updated
2023-06-02
Healthy Volunteers
Yes
Conditions
Interventions
Mirtazapine
Use of 3.75mg mirtazapine before lights-out during first 2 weeks after TKA surgery. With insufficient effect on sleep, patients are allowed to increase medication to 7.5mg mirtazapine.
Quetiapine
Use of 3.125mg quetiapine before lights-out during first 2 weeks after TKA surgery. With insufficient effect on sleep, patients are allowed to increase medication to 6.25mg mirtazapine.
Placebo
a gelatinous capsule without an active ingredient
Locations (2)
Knowledge Center for Orthopedic Surgery, St. Anna hospital
Geldrop, Netherlands
St. Anna hospital
Geldrop, Netherlands