Clinical Research Directory
Browse clinical research sites, groups, and studies.
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Sponsor: Merck Sharp & Dohme LLC
Summary
The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).
Official title: A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With Hematologic Malignancies
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
490
Start Date
2021-04-05
Completion Date
2029-01-04
Last Updated
2026-04-03
Healthy Volunteers
No
Conditions
Interventions
Nemtabrutinib
Nemtabrutinib tablets administered orally QD.
Locations (121)
Highlands Oncology Group ( Site 2728)
Springdale, Arkansas, United States
University of California San Diego Moores Cancer Center ( Site 2717)
La Jolla, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724)
Torrance, California, United States
Colorado Blood Cancer Institute ( Site 2726)
Denver, Colorado, United States
The University of Louisville, James Graham Brown Cancer Center ( Site 2729)
Louisville, Kentucky, United States
Mayo Clinic - Rochester ( Site 2706)
Rochester, Minnesota, United States
Astera Cancer Care ( Site 2732)
East Brunswick, New Jersey, United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704)
Hackensack, New Jersey, United States
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708)
Fargo, North Dakota, United States
UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730)
Dallas, Texas, United States
Medical Oncology Associates (Summit Cancer Centers) ( Site 2710)
Spokane, Washington, United States
Hospital Aleman ( Site 0102)
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103)
Buenos Aires, Buenos Aires F.D., Argentina
Fundacion Estudios Clinicos ( Site 0112)
Rosario, Santa Fe Province, Argentina
FUNDALEU ( Site 0104)
Caba, Argentina
Hospital Privado Universitario de Córdoba ( Site 0107)
Córdoba, Argentina
Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110)
Mendoza, Argentina
Nepean Hospital-Nepean Cancer Care Centre ( Site 0204)
Sydney, New South Wales, Australia
Box Hill Hospital ( Site 0203)
Box Hill, Victoria, Australia
Sir Charles Gairdner Hospital ( Site 0200)
Nedlands, Western Australia, Australia
Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303)
São Paulo, São Paulo, Brazil
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300)
Rio de Janeiro, Brazil
BP - A Beneficencia Portuguesa de São Paulo ( Site 0302)
São Paulo, Brazil
Hospital Paulistano - Amil Clinical Research ( Site 0311)
São Paulo, Brazil
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401)
Calgary, Alberta, Canada
The Ottawa Hospital ( Site 0404)
Ottawa, Ontario, Canada
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0406)
Toronto, Ontario, Canada
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0403)
Montreal, Quebec, Canada
Jewish General Hospital ( Site 0400)
Montreal, Quebec, Canada
Anhui Provincial Hospital ( Site 2808)
Hefei, Anhui, China
Peking University Third Hospital-Hematology ( Site 2827)
Beijing, Beijing Municipality, China
The Second Affiliated Hospital of Chongqing Medical University ( Site 2825)
Chongqing, Chongqing Municipality, China
Sun Yat-sen University Cancer Center-Internal Medicine ( Site 2824)
Guangzhou, Guangdong, China
Liuzhou People's Hospital ( Site 2817)
Liuchow, Guangxi, China
Guangxi Medical University Cancer Hospital ( Site 2814)
Nanning, Guangxi, China
Henan Cancer Hospital-hematology department ( Site 2802)
Zhengzhou, Henan, China
Wuhan Union Hospital ( Site 2816)
Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University ( Site 2820)
Changsha, Hunan, China
Hunan Cancer Hospital ( Site 2822)
Changsha, Hunan, China
Jiangsu Province Hospital ( Site 2823)
Nanjing, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical College ( Site 2818)
Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University ( Site 2815)
Nanchang, Jiangxi, China
The First Hospital of Jilin University-Hematology ( Site 2803)
Changchun, Jilin, China
Fudan University Shanghai Cancer Center ( Site 2801)
Shanghai, Shanghai Municipality, China
Huashan Hospital, Fudan University ( Site 2821)
Shanghai, Shanghai Municipality, China
West China Hospital Sichuan University ( Site 2810)
Chengdu, Sichuan, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Unio ( Site 2800)
Tianjin, Tianjin Municipality, China
The First Affiliated Hospital, Zhejiang University ( Site 2826)
Hangzhou, Zhejiang, China
Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0600)
Brno, Brno-mesto, Czechia
Fakultni nemocnice Hradec Kralove ( Site 0601)
Hradec Králové, Czechia
Aarhus University Hospital ( Site 0702)
Aarhus N, Central Jutland, Denmark
Aalborg Universitetshospital ( Site 0703)
Aalborg, North Denmark, Denmark
Sjaellands Universitetshospital Roskilde ( Site 0701)
Roskilde, Region Sjælland, Denmark
Odense University Hospital ( Site 0705)
Odense C, Region Syddanmark, Denmark
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0810)
Nice, Alpes-Maritimes, France
Centre Hospitalier Lyon-Sud ( Site 0804)
Pierre-Bénite, Auvergne-Rhône-Alpes, France
Institut Paoli-Calmettes ( Site 0803)
Marseille, Bouches-du-Rhone, France
Centre Hospitalier de Versailles ( Site 0809)
Le Chesnay, Yvelines, France
Hopital Saint Louis ( Site 0805)
Paris, France
Universitaetsklinikum Ulm. ( Site 0906)
Ulm, Baden-Wurttemberg, Germany
Universitaetsklinikum Koeln ( Site 0901)
Cologne, North Rhine-Westphalia, Germany
St. Marien-Krankenhaus Siegen ( Site 0914)
Siegen, North Rhine-Westphalia, Germany
Universitaetsklinikum Carl Gustav Carus ( Site 0902)
Dresden, Saxony, Germany
Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar ( Site 1202)
Pécs, Baranya, Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 1201)
Debrecen, Hajdú-Bihar, Hungary
Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1206)
Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary
Orszagos Onkologiai Intezet ( Site 1200)
Budapest, Hungary
Beaumont Hospital ( Site 2900)
Dublin, Ireland
University Hospital Limerick ( Site 2903)
Limerick, Ireland
Ha Emek Medical Center ( Site 1305)
Afula, Israel
Soroka Medical Center ( Site 1307)
Beersheba, Israel
Rambam Medical Center ( Site 1301)
Haifa, Israel
Hadassah Ein Karem Jerusalem ( Site 1300)
Jerusalem, Israel
Chaim Sheba Medical Center ( Site 1302)
Ramat Gan, Israel
Kaplan Medical Center ( Site 1304)
Rehovot, Israel
Sourasky Medical Center ( Site 1303)
Tel Aviv, Israel
Istituto Tumori Giovanni Paolo II ( Site 1409)
Bari, Italy
A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 1400)
Bologna, Italy
ASST Spedali Civili di Brescia ( Site 1408)
Brescia, Italy
IRCCS Ospedale San Raffaele ( Site 1402)
Milan, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1403)
Naples, Italy
Fondazione IRCCS Policlinico San Matteo ( Site 1407)
Pavia, Italy
IRCCS - Arcispedale Santa Maria Nuova ( Site 1405)
Reggio Emilia, Italy
Policlinico Umberto I ( Site 1404)
Roma, Italy
Pratia MCM Krakow ( Site 1601)
Krakow, Lesser Poland Voivodeship, Poland
Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site 1606)
Wroclaw, Lower Silesian Voivodeship, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1608)
Warsaw, Masovian Voivodeship, Poland
Szpital Wojewódzki w Opolu-Hematology Department ( Site 1607)
Opole, Opole Voivodeship, Poland
Szpitale Pomorskie Sp. z o.o. ( Site 1600)
Gdynia, Pomeranian Voivodeship, Poland
Spitalul Clinic Colțea ( Site 1805)
Bucharest, București, Romania
Ovidius Clinical Hospital ( Site 1804)
Ovidiu, Constanța County, Romania
Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 1802)
Brasov, Romania
Institutul Regional de Oncologie Iasi ( Site 1801)
Iași, Romania
Severance Hospital Yonsei University Health System ( Site 2201)
Seoul, South Korea
Samsung Medical Center ( Site 2200)
Seoul, South Korea
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 2000)
L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario de Salamanca ( Site 2002)
Salamanca, Castille and León, Spain
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2005)
A Coruña, La Coruna, Spain
Hospital General Universitario de Alicante ( Site 2007)
Alicante, Spain
Hospital Universitari Vall d'Hebron ( Site 2001)
Barcelona, Spain
Hospital Universitario 12 de Octubre ( Site 2003)
Madrid, Spain
Hospital Puerta de Hierro ( Site 2009)
Madrid, Spain
Inselspital Bern ( Site 2303)
Bern, Canton of Bern, Switzerland
Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 2302)
Bellinzona, Canton Ticino, Switzerland
Mega Medipol-Hematology ( Site 2406)
Stanbul, Istanbul, Turkey (Türkiye)
Ankara Universitesi Tip Fakultesi Cebeci Hastanesi ( Site 2400)
Ankara, Turkey (Türkiye)
VKV Amerikan Hastanesi ( Site 2403)
Istanbul, Turkey (Türkiye)
Sisli Florence Nightingale Hastanesi ( Site 2407)
Istanbul, Turkey (Türkiye)
Dokuz Eylül Üniversitesi-Hematology ( Site 2402)
Izmir, Turkey (Türkiye)
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2509)
Cherkassy, Cherkasy Oblast, Ukraine
Communal non-profit enterprise "Regional clinical hospital o-Hematology Department ( Site 2510)
Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine
Instit. of Blood Transfusion Medicine of the National Academy ( Site 2506)
Lviv, Lviv Oblast, Ukraine
National Cancer Institute ( Site 2507)
Kyiv, Ukraine
Bristol Haematology and Oncology Centre ( Site 2610)
Bristol, Bristol, City of, United Kingdom
Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601)
Nottingham, England, United Kingdom
GenesisCare - Windsor ( Site 2608)
Windsor, England, United Kingdom
Sarah Cannon Research Institute UK ( Site 2612)
London, London, City of, United Kingdom
GenesisCare - Oxford ( Site 2607)
Oxford, Oxfordshire, United Kingdom
GenesisCare - Cambridge ( Site 2611)
Newmarket, Suffolk, United Kingdom
The Royal Marsden NHS Foundation Trust. ( Site 2606)
Sutton, Surrey, United Kingdom
The Christie NHS Foundation Trust ( Site 2602)
Manchester, United Kingdom