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ACTIVE NOT RECRUITING
NCT04736706
PHASE3

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell carcinoma (ccRCC). The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to progression-free survival (PFS) and overall survival (OS), in advanced ccRCC participants; and (2) pembrolizumab/quavonlimab plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to PFS and OS, in advanced ccRCC participants.

Official title: An Open-label, Randomized Phase 3 Study to Evaluate Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or MK-1308A in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, as First-Line Treatment in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1653

Start Date

2021-04-14

Completion Date

2026-10-29

Last Updated

2024-11-18

Healthy Volunteers

No

Interventions

BIOLOGICAL

Pembrolizumab

Pembrolizumab 400 mg administered Q6W via IV infusion

DRUG

Belzutifan

Belzutifan 120 mg administered QD via oral tablet

BIOLOGICAL

Pembrolizumab/Quavonlimab

Pembrolizumab/quavonlimab is a co-formulated product composed of pembrolizumab 400 mg in combination with quavonlimab 25 mg, administered Q6W via IV infusion

DRUG

Lenvatinib

Lenvatinib 20 mg administered QD via oral capsule

Locations (262)

The University of Alabama at Birmingham ( Site 0010)

Birmingham, Alabama, United States

UC San Diego ( Site 0050)

La Jolla, California, United States

Cedars Sinai Medical Center ( Site 0027)

Los Angeles, California, United States

University of California Irvine ( Site 0029)

Orange, California, United States

UCLA Hematology Oncology Santa Monica ( Site 0048)

Santa Monica, California, United States

Hartford Hospital ( Site 0024)

Hartford, Connecticut, United States

Advent Health Hematology & Oncology ( Site 0003)

Orlando, Florida, United States

University Cancer & Blood Center, LLC ( Site 0057)

Athens, Georgia, United States

Emory University Winship Cancer Institute ( Site 0012)

Atlanta, Georgia, United States

Rush University Medical Center ( Site 0040)

Chicago, Illinois, United States

Parkview Cancer Institute ( Site 0088)

Fort Wayne, Indiana, United States

Norton Cancer Institute - St. Matthews ( Site 0065)

Louisville, Kentucky, United States

Ochsner Medical Center ( Site 0049)

New Orleans, Louisiana, United States

New England Cancer Specialists ( Site 0082)

Scarborough, Maine, United States

Massachusetts General Hospital ( Site 0094)

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center ( Site 0089)

Boston, Massachusetts, United States

Dana Farber Cancer Institute ( Site 0093)

Boston, Massachusetts, United States

Lahey Hospital & Medical Center ( Site 0090)

Burlington, Massachusetts, United States

Henry Ford Hospital ( Site 0038)

Detroit, Michigan, United States

Cancer & Hematology Centers of Western Michigan ( Site 0018)

Grand Rapids, Michigan, United States

HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0005)

Saint Louis Park, Minnesota, United States

Regions Hospital ( Site 0095)

Saint Paul, Minnesota, United States

University of Mississippi Medical Center ( Site 0037)

Jackson, Mississippi, United States

Dartmouth Hitchcock Medical Center ( Site 0075)

Lebanon, New Hampshire, United States

Roswell Park Cancer Institute ( Site 0032)

Buffalo, New York, United States

R.J. Zuckerberg Cancer Center-Medical Oncology ( Site 0013)

Lake Success, New York, United States

Sidney Kimmel Center for Prostate and Urologic Cancers ( Site 0055)

New York, New York, United States

Oregon Health & Science University ( Site 0071)

Portland, Oregon, United States

Ralph H. Johnson VA Center ( Site 0073)

Charleston, South Carolina, United States

University of Tennessee Medical Center Knoxville ( Site 0019)

Knoxville, Tennessee, United States

Vanderbilt University Medical Center ( Site 0069)

Nashville, Tennessee, United States

UTSW Medical Center ( Site 0015)

Dallas, Texas, United States

Central Washington Health Services Association d/b/a Confluence Health ( Site 0061)

Wenatchee, Washington, United States

Liverpool Hospital ( Site 4006)

Liverpool, New South Wales, Australia

Macquarie University ( Site 4007)

Macquarie University, New South Wales, Australia

Lyell McEwin Hospital ( Site 4004)

Elizabeth Vale, South Australia, Australia

Monash Health ( Site 4008)

Clayton, Victoria, Australia

Fiona Stanley Hospital ( Site 4009)

Murdock, Western Australia, Australia

Oncocentro Ceara ( Site 0309)

Fortaleza, Ceará, Brazil

Centro de Pesquisas Clinicas em Oncologia ( Site 0306)

Cachoeiro de Itapemirim, Espírito Santo, Brazil

Centro Avançado de Tratamento Oncológico- CENATRON-Clinical Research ( Site 0303)

Belo Horizonte, Minas Gerais, Brazil

Liga Norte Riograndense Contra o Cancer ( Site 0308)

Natal, Rio Grande do Norte, Brazil

Hospital de Clinicas de Porto Alegre ( Site 0310)

Porto Alegre, Rio Grande do Sul, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0302)

São Paulo, Brazil

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0300)

São Paulo, Brazil

A.C. Camargo Cancer Center ( Site 0301)

São Paulo, Brazil

Tom Baker Cancer Centre ( Site 0119)

Calgary, Alberta, Canada

BC Cancer - Vancouver Center ( Site 0120)

Vancouver, British Columbia, Canada

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0117)

Hamilton, Ontario, Canada

Sunnybrook Research Institute ( Site 0116)

Toronto, Ontario, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0

Québec, Quebec, Canada

IC La Serena Research ( Site 0403)

La Serena, Coquimbo Region, Chile

Servicios Medicos Urumed ( Site 0405)

Rancagua, Lbtdr Gen Bernardo O Higgins, Chile

Fundacion Arturo Lopez Perez ( Site 0400)

Santiago, Region M. de Santiago, Chile

Bradfordhill-Clinical Area ( Site 0401)

Santiago, Region M. de Santiago, Chile

Centro Investigacion Cancer James Lind ( Site 0402)

Temuco, Región de la Araucanía, Chile

The First Afflilated Hospital of Bengbu Medical College-Urology Surgery ( Site 6041)

Bengbu, Anhui, China

Cancer Hospital Chinese Academy of Medical Science-Oncology ( Site 6026)

Beijing, Beijing Municipality, China

Peking University First Hospital ( Site 6011)

Beijing, Beijing Municipality, China

Beijing Cancer hospital-Renal carcinoma and melanoma ( Site 6000)

Beijing, Beijing Municipality, China

Chongqing University Cancer Hospital ( Site 6009)

Chongqing, Chongqing Municipality, China

The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 6038)

Fuzhou, Fujian, China

The First Affiliated hospital of Xiamen University-Urology ( Site 6001)

Xiamen, Fujian, China

SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 6003)

Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou Medical University-Urology ( Site 6036)

Guangzhou, Guangdong, China

Guangzhou First People's Hospital ( Site 6007)

Guangzhou, Guangdong, China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Urology Surgery ( Site 6005)

Guangzhou, Guangdong, China

Harbin Medical University Cancer Hospital-urology ( Site 6015)

Harbin, Heilongjiang, China

Henan Cancer Hospital-Urology ( Site 6006)

Zhengzhou, Henan, China

Wuhan Union Hospital ( Site 6002)

Wuhan, Hubei, China

Xiangya Hospital Central South University ( Site 6034)

Changsha, Hunan, China

Hunan Cancer Hospital ( Site 6020)

Changsha, Hunan, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S

Nanjing, Jiangsu, China

The Second Affiliated Hospital of Soochow University-Urology ( Site 6025)

Suzhou, Jiangsu, China

The First Affiliated Hospital of Nanchang University ( Site 6019)

Nanchang, Jiangxi, China

Jiangxi Provincial Cancer Hospital ( Site 6042)

Nanchang, Jiangxi, China

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 6014)

Xi'an, Shaanxi, China

Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 6017)

Shanghai, Shanghai Municipality, China

Shanghai Tenth People's Hospital ( Site 6023)

Shanghai, Shanghai Municipality, China

West China Hospital Sichuan University-Urology Surgery ( Site 6016)

Chengdu, Sichuan, China

Tianjin Medical University Cancer Institute and Hospital ( Site 6029)

Tianjin, Tianjin Municipality, China

The Second Hospital of Tianjin Medical University ( Site 6032)

Tianjin, Tianjin Municipality, China

The First Affiliated Hospital, Zhejiang University ( Site 6024)

Hangzhou, Zhejiang, China

The First Hospital of Jiaxing ( Site 6033)

Jiaxing, Zhejiang, China

Ningbo First Hospital-Urology ( Site 6028)

Ningbo, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 6021)

Wenzhou, Zhejiang, China

Instituto de Cancerología S.A Clínica de las Americas (ICCLA) ( Site 0500)

Medellín, Antioquia, Colombia

Clinica de la Costa S.A.S. ( Site 0502)

Barranquilla, Atlántico, Colombia

Administradora Country SA - Clinica del Country ( Site 0504)

Bogotá, Bogota D.C., Colombia

Instituto Nacional de Cancerología E.S.E. ( Site 0503)

Bogotá, Bogota D.C., Colombia

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0505)

Valledupar, Cesar Department, Colombia

Oncólogos del Occidente S.A ( Site 0501)

Pereira, Risaralda Department, Colombia

Fundacion Cardiovascular de Colombia ( Site 0506)

Piedecuesta, Santander Department, Colombia

Klinicki Bolnicki Centar Zagreb ( Site 3200)

Zagreb, City of Zagreb, Croatia

Klinički Bolnički Centar Split ( Site 3202)

Split, Split-Dalmatia County, Croatia

Klinicki bolnicki centar "Sestre milosrdnice" ( Site 3201)

Zagreb, Zagreb County, Croatia

Masarykuv onkologicky ustav ( Site 2203)

Brno, Brno-mesto, Czechia

Nemocnice AGEL Novy Jicin a.s. ( Site 2202)

Nový Jičín, Moravskoslezský kraj, Czechia

Fakultni nemocnice Ostrava ( Site 2208)

Ostrava, Moravskoslezský kraj, Czechia

Fakultni nemocnice u sv. Anny v Brne ( Site 2205)

Brno, South Moravian, Czechia

Fakultni nemocnice Olomouc ( Site 2200)

Olomouc, Czechia

Fakultni Thomayerova nemocnice ( Site 2201)

Prague, Czechia

2 LF UK a FN Motol ( Site 2207)

Prague, Czechia

Herlev Hospital ( Site 1700)

Herlev, Capital Region, Denmark

Odense University Hospital ( Site 1701)

Odense, Region Syddanmark, Denmark

Kuopion Yliopistollinen Sairaala ( Site 1803)

Kuopio, Northern Savonia, Finland

TAYS ( Site 1801)

Tampere, Pirkanmaa, Finland

TYKS ( Site 1802)

Turku, Southwest Finland, Finland

HYKS ( Site 1800)

Helsinki, Uusimaa, Finland

Institut Paoli Calmettes ( Site 1206)

Marseille, Bouches-du-Rhone, France

CHU Jean Minjoz ( Site 1205)

Besançon, Doubs, France

Institut Claudius Regaud ( Site 1214)

Toulouse, Haute-Garonne, France

Clinique Francois Chenieux ( Site 1209)

Limoges, Haute-Vienne, France

Clinique Ambroise Pare Beuvry ( Site 1213)

Beuvry, Hauts-de-France, France

CHU Angers ( Site 1200)

Angers, Maine-et-Loire, France

CH Lyon Sud Hospices Civils de Lyon ( Site 1203)

Pierre-Bénite, Rhone, France

Gustave Roussy ( Site 1207)

Villejuif, Val-de-Marne, France

Hopital Tenon ( Site 1212)

Paris, France

Universitaetsklinik fuer Urologie ( Site 1300)

Tübingen, Baden-Wurttemberg, Germany

Helios Kliniken Schwerin GmbH ( Site 1302)

Schwerin, Mecklenburg-Vorpommern, Germany

Charite Universitaetsmedizin Berlin ( Site 1301)

Berlin, Germany

Centro Medico Integral de Cancerologia CEMIC ( Site 0701)

Salcajá, Departamento de Quetzaltenango, Guatemala

Oncomedica ( Site 0700)

Guatemala City, Guatemala

Grupo Angeles SA ( Site 0705)

Guatemala City, Guatemala

Sanatorio Nuestra Senora del Pilar ( Site 0702)

Guatemala City, Guatemala

Medi-K Cayala ( Site 0703)

Guatemala City, Guatemala

Centro Regional de Sub Especialidades Medicas SA ( Site 0704)

Quetzaltenango, Guatemala

Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 2309)

Gyula, Bekes County, Hungary

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2308)

Kecskemét, Bács-Kiskun county, Hungary

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 2300)

Szolnok, Jász-Nagykun-Szolnok, Hungary

Markusovszky Egyetemi Oktatokorhaz ( Site 2303)

Szombathely, Vas County, Hungary

Orszagos Onkologiai Intezet ( Site 2304)

Budapest, Hungary

Debreceni Egyetem Klinikai Kozpont ( Site 2301)

Debrecen, Hungary

Beaumont Hospital ( Site 6101)

Dublin, Ireland

Tallaght University Hospital ( Site 6100)

Dublin, Ireland

Azienda Ospedaliero - Universitaria Policlinico di Modena ( Site 1404)

Modena, Emilia-Romagna, Italy

Ospedale San Raffaele-Oncologia Medica ( Site 1417)

Milan, Lombardy, Italy

Fondazione Policlinico Universitario A. Gemelli ( Site 1414)

Rome, Roma, Italy

Azienda Ospedaliera Policlinico di Bari ( Site 1411)

Bari, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1409)

Milan, Italy

Istituto Nazionale Tumori Fondazione Pascale ( Site 1412)

Naples, Italy

Azienda Ospedaliera S. Maria di Terni ( Site 1410)

Terni, Italy

Fujita Health University ( Site 5003)

Toyoake, Aichi-ken, Japan

Chiba cancer center ( Site 5021)

Chiba, Chiba, Japan

National Cancer Center Hospital East ( Site 5000)

Kashiwa, Chiba, Japan

Ehime University Hospital ( Site 5020)

Tōon, Ehime, Japan

Sapporo Medical University Hospital ( Site 5008)

Sapporo, Hokkaido, Japan

Hokkaido University Hospital ( Site 5013)

Sapporo, Hokkaido, Japan

Kanagawa cancer center ( Site 5016)

Yokohama, Kanagawa, Japan

Nara Medical University Hospital ( Site 5002)

Kashihara, Nara, Japan

Kindai University Hospital- Osakasayama Campus-Urology ( Site 5010)

Sayama, Osaka, Japan

Osaka University Hospital ( Site 5012)

Suita, Osaka, Japan

Saitama Medical University International Medical Center ( Site 5015)

Hidaka, Saitama, Japan

Hamamatsu University School of Medicine University Hospital ( Site 5004)

Hamamatsu, Shizuoka, Japan

Tokyo Medical And Dental University Medical Hospital-Urology ( Site 5009)

Bunkyō, Tokyo, Japan

Toranomon Hospital ( Site 5001)

Minato-ku, Tokyo, Japan

Toyama University Hospital ( Site 5014)

Toyoma, Toyama, Japan

Kyushu University Hospital ( Site 5005)

Fukuoka, Japan

Kumamoto University ( Site 5022)

Kumamoto, Japan

Niigata University Medical & Dental Hospital ( Site 5024)

Niigata, Japan

Okayama University Hospital ( Site 5017)

Okayama, Japan

Tokushima University Hospital-Department of Urology ( Site 5019)

Tokushima, Japan

Nippon Medical School Hospital ( Site 5006)

Tokyo, Japan

Tokyo Women's Medical University Adachi Medical Center ( Site 5023)

Tokyo, Japan

Keio university hospital ( Site 5011)

Tokyo, Japan

Hospital Sultan Ismail ( Site 4303)

Johor Bahru, Johor, Malaysia

Institut Kanser Negara - National Cancer Institute ( Site 4302)

Putrajaya, Putrajaya, Malaysia

Hospital Kuala Lumpur ( Site 4301)

Kuala Lumpur, Malaysia

Universiti Malaya Medical Centre ( Site 4300)

Kuala Lumpur, Malaysia

Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0610)

Guadalajara, Jalisco, Mexico

Instituto Nacional de Cancerologia ( Site 0602)

Mexico City, Mexico City, Mexico

I CAN Oncology SA de SV ( Site 0601)

Monterrey, Nuevo León, Mexico

Hospital H+ Queretaro-Cuidados Oncológicos ( Site 0608)

Querétaro City, Querétaro, Mexico

Centro de Investigacion Clinica de Oaxaca ( Site 0605)

Oaxaca City, Mexico

Akershus universitetssykehus ( Site 2000)

Lorenskog, Akershus, Norway

Soerlandet sykehus HF Kristiansand ( Site 2007)

Kristiansand, Aust-Agder, Norway

Helse Bergen HF - Haukeland Universitetssykehus ( Site 2002)

Bergen, Hordaland, Norway

St. Olavs Hospital HF ( Site 2005)

Trondheim, Sor-Trondelag, Norway

Oslo Universitetssykehus Radiumhospitalet ( Site 2001)

Oslo, Norway

Sykehuset Østfold HF Kalnes ( Site 2003)

Grålum, Østfold fylke, Norway

Manila Doctors Hospital ( Site 4601)

Manila, National Capital Region, Philippines

The Medical City ( Site 4602)

Pasig, National Capital Region, Philippines

Cardinal Santos Medical Center ( Site 4603)

San Juan City, National Capital Region, Philippines

Przychodnia Lekarska KOMED ( Site 2419)

Konin, Greater Poland Voivodeship, Poland

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2406)

Poznan, Greater Poland Voivodeship, Poland

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2420)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Radomskie Centrum Onkologii ( Site 2418)

Radom, Masovian Voivodeship, Poland

Luxmed Onkologia sp. z o. o. ( Site 2412)

Warsaw, Masovian Voivodeship, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2405)

Warsaw, Masovian Voivodeship, Poland

Szpital Wojewodzki im. Mikolaja Kopernika ( Site 2407)

Koszalin, West Pomeranian Voivodeship, Poland

Spitalul Judetean de Urgenta Alba Iulia ( Site 2502)

Alba Iulia, Alba, Romania

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2501)

Craiova, Dolj, Romania

Policlinica Oncomed SRL ( Site 2506)

Timișoara, Timiș County, Romania

S.C.Focus Lab Plus S.R.L ( Site 2503)

Bucharest, Romania

Altay Regional Oncology Dispensary ( Site 2610)

Barnaul, Altayskiy Kray, Russia

Ivanovo Regional Oncology Dispensary ( Site 2615)

Ivanovo, Ivanovo Oblast, Russia

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 2609)

Krasnoyarsk, Krasnoyarsk Krai, Russia

The Loginov Moscow Clinical Scientific Center ( Site 2604)

Moscow, Moscow, Russia

Moscow Oncological Clinical Dispensary #1 ( Site 2619)

Moscow, Moscow, Russia

FBHI Privolzhsky District Medical Center of the FMBA ( Site 2611)

Nizhny Novgorod, Nizhny Novgorod Oblast, Russia

Nizhniy Novgorod Region Oncology Dispensary ( Site 2621)

Nizhny Novgorod, Nizhny Novgorod Oblast, Russia

Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2617)

Saint Petersburg, Sankt-Peterburg, Russia

City clinical oncological dispensary ( Site 2605)

Saint Petersburg, Sankt-Peterburg, Russia

Klinicki centar Srbije. ( Site 3333)

Belgrade, Beograd, Serbia

Klinicki centar Nis ( Site 3322)

Niš, Nisavski Okrug, Serbia

Institut za onkologiju Vojvodine ( Site 3311)

Kamenitz, Sremski Okrug, Serbia

Cancer Care Langenhoven Drive Oncology Centre ( Site 3009)

Port Elizabeth, Eastern Cape, South Africa

Wits Clinical Research ( Site 3012)

Johannesburg, Gauteng, South Africa

Sandton Oncology Medical Group PTY LTD ( Site 3000)

Johannesburg, Gauteng, South Africa

Univ. Pretoria and Steve Biko Academic Hospitals ( Site 3002)

Pretoria, Gauteng, South Africa

Life Wilgers Hospital ( Site 3004)

Pretoria, Gauteng, South Africa

Mary Potter Oncology Centre, Little Company of Mary Hospital ( Site 3001)

Pretoria, Gauteng, South Africa

Vaal Triangle Oncology Centre ( Site 3010)

Vereeniging, Gauteng, South Africa

Groote Schuur Hospital ( Site 3011)

Cape Town, Western Cape, South Africa

Cape Town Oncology Trials Pty Ltd ( Site 3006)

Kraaifontein, Western Cape, South Africa

Cancercare Rondebosch Oncology ( Site 3005)

Rondebosch, Western Cape, South Africa

National Cancer Center ( Site 4202)

Goyang-si, Kyonggi-do, South Korea

Chungnam National University Hospital ( Site 4205)

Daejeon, Taejon-Kwangyokshi, South Korea

Korea University Anam Hospital ( Site 4206)

Seoul, South Korea

Seoul National University Hospital ( Site 4201)

Seoul, South Korea

Severance Hospital Yonsei University Health System ( Site 4204)

Seoul, South Korea

Asan Medical Center ( Site 4203)

Seoul, South Korea

Samsung Medical Center ( Site 4200)

Seoul, South Korea

Instituto Catalan de Oncologia - ICO ( Site 1502)

L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Universitario Marques de Valdecilla ( Site 1501)

Santander, Cantabria, Spain

Institut Català d'Oncologia (ICO) - Girona ( Site 1500)

Girona, Gerona, Spain

Hospital Clinico San Carlos ( Site 1503)

Madrid, Spain

Hospital Universitario 12 de Octubre ( Site 1505)

Madrid, Spain

Hospital Universitario Virgen de la Victoria ( Site 1504)

Málaga, Spain

Lanssjukhuset Ryhov ( Site 2103)

Jönköping, Jönköping County, Sweden

Karolinska Universitetssjukhuset Solna ( Site 2100)

Stockholm, Stockholm County, Sweden

Akademiska Sjukhuset ( Site 2105)

Uppsala, Uppsala County, Sweden

Norrlands Universitetssjukhus ( Site 2106)

Umeå, Västerbotten County, Sweden

Sahlgrenska Universitetssjukhuset ( Site 2102)

Gothenburg, Västra Götaland County, Sweden

Chang Gung Medical Foundation. Kaohsiung Branch ( Site 4405)

Kaohsiung City, Taiwan

Taichung Veterans General Hospital ( Site 4403)

Taichung, Taiwan

National Cheng Kung University Hospital ( Site 4404)

Tainan, Taiwan

National Taiwan University Hospital ( Site 4401)

Taipei, Taiwan

Taipei Veterans General Hospital ( Site 4402)

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 4406)

Taoyuan District, Taiwan

Ramathibodi Hospital. ( Site 4500)

Bangkok, Bangkok, Thailand

Siriraj Hospital ( Site 4501)

Bangkok, Bangkok, Thailand

Ankara Universitesi Tip Fakultesi ( Site 2902)

Ankara, Turkey (Türkiye)

Hacettepe Universitesi Tıp Fakultesi ( Site 2903)

Ankara, Turkey (Türkiye)

Trakya University Medical Faculty Balkan Oncology Hospital ( Site 2906)

Edirne, Turkey (Türkiye)

Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2900)

Istanbul, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2901)

Istanbul, Turkey (Türkiye)

Ege Universitesi Tip Fakultesi Hastanesi ( Site 2904)

Izmir, Turkey (Türkiye)

Dokuz Eylul Universitesi Tip Fakultesi Hastanesi ( Site 2905)

Izmir, Turkey (Türkiye)

Cherkasy Regional Oncology Dispensary ( Site 2704)

Cherkasy, Cherkasy Oblast, Ukraine

Chernihiv Medical Center of Modern Oncology ( Site 2709)

Chernihiv, Chernihiv Oblast, Ukraine

Clinical oncology dispensary of Dnipro ( Site 2700)

Dnipro, Dnipropetrovsk Oblast, Ukraine

ME І.І. Mechnykov Dnipro Regional Clinical Hospital ( Site 2710)

Dnipropetrovsk, Dnipropetrovsk Oblast, Ukraine

Ivano-Frankivsk Regional Hospital-Urology department ( Site 2707)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

Ivano-Frankivsk Regional Oncology Clinical Dispensary ( Site 2711)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

Regional Oncology Center of Kharkiv ( Site 2708)

Kharkiv, Kharkivs’ka Oblast’, Ukraine

Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 2715)

Kharkiv, Kharkivs’ka Oblast’, Ukraine

Kyiv City Clinical Oncology Center ( Site 2706)

Kyiv, Kyivska Oblast, Ukraine

Lviv State Regional Oncological Center ( Site 2712)

Lviv, Lviv Oblast, Ukraine

Addenbrookes Hospital ( Site 3110)

Cambridge, Cambridgeshire, United Kingdom

Barts Health NHS Trust - St Bartholomew s Hospital ( Site 3116)

London, England, United Kingdom

Mount Vernon Cancer Centre ( Site 3101)

Northwood, London, City of, United Kingdom