Clinical Research Directory
Browse clinical research sites, groups, and studies.
Determining Airway pH by Compartmental Exhaled Nitric Oxide Levels During Alkaline Buffer Challenge
Sponsor: Indiana University
Summary
Airway pH imbalances cause numerous adverse physiological changes within the airways, including hyperreactivity, cough, bronchoconstriction, ciliopathy, decreased response to bronchodilators, bacterial growth, nitrosative/oxidative stress, neutrophilic/eosinophilic inflammation, and cell death. Airway pH is known to be low (acidic) in chronic and acute pulmonary diseases. The gold standard approach to measuring airway pH is to bronchscopically obtain epithelial cell lining fluid using protected brush sampling. The expense and invasive nature of this approach is a barrier to fully characterizing the role of airway pH in the health and disease. In this study, we will evaluate non-invasive clinical methods that can be done using equipment standard in clinical pulmonary function laboratories for measuring airway pH.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2020-09-11
Completion Date
2028-07-15
Last Updated
2025-12-09
Healthy Volunteers
Yes
Conditions
Interventions
Alkaline glycine
Subjects will inhale alkaline glycine via nebulizer. Alkaline glycine is an alkaline medication designed for medication.
Locations (1)
Indiana University School of Medicine
Indianapolis, Indiana, United States