Clinical Research Directory

Inclusion Criteria: DISEASE CHARACTERISTICS (Meets all of the following criteria): Patients who have a primary diagnosis of solid tumor cancer at any stage that are within 12 weeks +/- of starting treatment, which includes either infusion chemo- or immunotherapy, oral targeted agents, or both. PATIENT CHARACTERISTICS: * Patients who have a primary diagnosis of soled tumor cancer at any stage that are within 12 weeks of initiating treatment. * Patient must be spouse or partner of the caregiver for at least a year and must live with caregiver * Must be able to read/speak English * 18 years of age or older CAREGIVER CHARACTERISTICS: * A primary caregiver for the patient with a diagnosis of solid tumor cancer at any stage who are within 12 weeks of initiating treatment * Spouse or partner of the patient for at least a year * The caregiver must live with the patient * Must be available to fully participate in an intervention (Virtual-PEPRR or PepPal) if assigned * Must score 1 or greater on the PHQ-2 (depression) and/or GAD-2 (anxiety) during pre-screening. * Must be employed at the time of the patient's diagnosis for a minimum of 20 hours/week with plans to remain employed and working during their patient's treatment. Caregivers that were furloughed or laid off due to Covid-19 who are actively looking for work will be included. * Able to read and speak the English language * Willingness to use a Smartphone * Age 25 (inclusive) 65 (non-inclusive) Exclusion Criteria: * Having a serious medical condition likely to influence neuroendocrine parameters * Chronic use of steroid medications * If Female, pregnant or planning to become pregnant in the next year * History of a psychiatric illness unrelated to their experience as a caregiver with the past 18 months.