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Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Sponsor: Baylor College of Medicine
Summary
Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigate the effects of supplementing glycine and N-acetylcysteine vs. alanine as placebo on these defects in AD, and examine the effects on cognition.
Key Details
Gender
All
Age Range
55 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
52
Start Date
2022-02-15
Completion Date
2026-12-31
Last Updated
2025-06-10
Healthy Volunteers
No
Conditions
Interventions
Glycine
The active arm will supplement a combination of glycine and N-acetylcysteine (GlyNAC)
N-acetylcysteine
The active arm will supplement a combination of glycine and N-acetylcysteine (GlyNAC)
Alanine
The placebo arm will supplement Alanine
Locations (1)
Baylor College of Medicine
Houston, Texas, United States