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Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
Sponsor: Centre Hospitalier Universitaire, Amiens
Summary
An increased risk of cardiovascular (CV) diseases has been observed in patients with inflammatory bowel diseases (IBD). The impact of IBD drugs, such as anti-TNF, anti-integrins or anti-JAK, on the risk of CV events in IBD is remains unknown. Aortic pulse wave velocity (aPWV), a measure of aortic stiffness, and carotid intima media thickness (CIMT) are both predictors of cardiovascular events and are increased in patients with IBD. The investigators aimed to prospectively compare the CV risk, CIMT, arterial stiffness and biomarkers of endothelial dysfunction at baseline and after 3 and 12 months of anti-TNF, vedolizumab and tofacitinib.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-02-02
Completion Date
2025-12
Last Updated
2025-05-29
Healthy Volunteers
No
Conditions
Interventions
Aortic pulse wave velocity
Aortic pulse wave velocity (aPWV) is a measure of aortic stiffness
carotid intima media thickness (CIMT)
carotid intima media thickness (CIMT)
Locations (1)
CHU Amiens
Amiens, France