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Microfluidics Versus Gradient Centrifugation Effect on Euploidy Rates
Sponsor: Lawrence Engmann
Summary
This research is being done to determine if using a microfluidics chamber, a device used to process sperm, will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that this device is effective at improving rates of normal chromosomes among embryos.
Official title: A Double-blind Prospective Randomized Clinical Trial Comparing Euploidy Rates Among Embryos Created From Sibling Oocytes Injected With Sperm Processed by Microfluidics or by Density Gradient Centrifugation
Key Details
Gender
FEMALE
Age Range
18 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2021-01-13
Completion Date
2022-12-31
Last Updated
2022-10-03
Healthy Volunteers
No
Conditions
Interventions
Microfluidics chamber
Unwashed sperm will be placed into the inlet chamber of the microfluidics device. The most motile sperm will swim to the outlet chamber, and these sperms will be used for intracytoplasmic sperm injection (ICSI) into the eggs.
Density Gradient Centrifugation
Sperm will be washed and centrifuged according to standard protocol, and these washed sperm will be used for ICSI.
Locations (1)
The Center for Advanced Reproductive Services
Farmington, Connecticut, United States