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Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis
Sponsor: Istituto Ortopedico Rizzoli
Summary
The aim of the present study is to evaluate the expression of a large panel of microRNAs, already known and validated in other ortopedic pathologies and bone metabolism, in the plasma of Adolescent Idiopathic Scoliosis (AIS) patients. The deregulated microRNAs identified will be then validated and computational analyzes will determine their potential involvement in the metabolism of bone and/or cartilage tissue in order to correlate the results obtained with the clinical data of the AIS patients. The investigators aimed to develop a microRNAs panel to further validate in a larger population of AIS patients in order to produce a device for the diagnosis and prognosis of Molecular-based AIS.
Official title: Identification and Characterization of Circulating microRNAs as Diagnostic Biomarkers in Adolescent Idiopathic Scoliosis
Key Details
Gender
All
Age Range
11 Years - 17 Years
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2020-07-22
Completion Date
2025-12-21
Last Updated
2025-01-27
Healthy Volunteers
Yes
Conditions
Interventions
Circulating MiRNA indentification
Identification of circulating miRNA useful to discriminate between worsening and stable forms of AIS
Locations (1)
Dipartimento Rizzoli-Sicilia
Bagheria, Italy