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Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection
Sponsor: Brii Biosciences Limited
Summary
This is an open label, randomized, parallel-group study to evaluate the safety and efficacy of combination treatment BRII-835 (VIR-2218) and BRII-179 (VBI-2601) in adult participants with chronic HBV infection
Official title: A Phase 2 Multicenter, Randomized, Open-label Study to Investigate the Safety and Efficacy of BRII-835 (VIR-2218) and BRII-179 (VBI-2601) Combination Therapy for the Treatment of Chronic Hepatitis B Virus (HBV) Infection
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
91
Start Date
2021-04-12
Completion Date
2023-07-04
Last Updated
2026-07-23
Healthy Volunteers
No
Conditions
Interventions
BRII-835 (VIR-2218)
BRII-835 (VIR-2218) will be given by subcutaneous injection
BRII-179 (VBI-2601) with IFN-α
BRII-179 (VBI-2601) with IFN-α will be co-administered by intramuscular injection
BRII-179 (VBI-2601)
BRII-179 (VBI-2601) will be administered by intramuscular injection
Locations (28)
Investigative Site 61002
Kingswood, New South Wales, Australia
Investigative Site 61001
Westmead, New South Wales, Australia
Investigative Site 61004
Herston, Queensland, Australia
Investigative Site 88602
Changhua, Taiwan, China
Investigative Site 85201
Hong Kong, China
Investigative Site 85202
Hong Kong, China
Investigative Site 85203
Hong Kong, China
Investigative Site 88601
Kaohsiung, Taiwan, China
Investigative Site 88604
Kaohsiung, Taiwan, China
Investigative Site 85204
NEW Territories, Hong Kong, China
Investigative Site 88603
Taichung, Taiwan, China
Investigative Site 88605
Taipei CITY, China
Investigative Site 64002
Dunedin Central, Dunedin, New Zealand
Investigative Site 64001
Auckland, New Zealand
Investigative Site 65001
Singapore, Singapore
Investigative Site 65002
Singapore, Singapore
Investigative Site 82004
Busan, South Korea
Investigative Site 82003
Seongnam-si, Gyeonggi-do, South Korea
Investigative Site 82001
Seoul, South Korea
Investigative Site 82005
Seoul, South Korea
Investigative Site 82002
Seoul, South Korea
Investigative Site 66001
Bangkok, Thailand
Investigative Site 66003
Chiang Mai, Thailand
Investigative Site 66002
Khon Kaen, Thailand
Investigative Site 66005
Nonthaburi, Thailand
Investigative Site 66006
Nonthaburi, Thailand
Investigative Site 66004
Pathum Thani, Thailand
Investigative Site 66007
Songkhla, Thailand