Clinical Research Directory

Inclusion Criteria: * Age 18 to 75 * Scheduled for same-day bilateral total knee replacements with participating surgeons * American Society of Anesthesiologists (ASA) Physical Status 1 or 2 Exclusion Criteria: * ASA 3 and higher * Weight \< 40kg * Planned use of general anesthesia * Contraindication to major components of study protocol * Cannabis or cannabinoid use within the past 3 months (recreational and/or medical) * Use or ingestion of hemp seeds or hemp oil in any form within the past 30 days * Chronic opioid use (\>3 months) * Coumadin use * Current use of SSRI or SNRIs * History of substance abuse or dependence * Active or history of major psychiatric illness * Severe cardiovascular disorder * Severe hepatic or renal insufficiency (transaminase levels above ULN) * History of epilepsy * Diagnosis of rheumatic disease, autoimmune disease, or immunodeficiency (e.g. rheumatoid arthritis, psoriatic arthritis, inflammatory bowel disease, multiple sclerosis, etc.) * Use of valproate or clobazam * Known or suspected hypersensitivity, allergy, or contraindication to cannabinoids or any of the excipients in the study medications (i.e. sesame oil, sucralose, strawberry flavor) * Active use of steroids - oral steroids upon admission * Stress dose steroids * Non-English speakers * Planned discharge to home without caregiver(s)