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Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
Sponsor: Anthos Therapeutics, Inc.
Summary
The purpose of the ANT-006 study is to evaluate the bleeding profile of abelacimab relative to rivaroxaban in patients with atrial fibrillation (AF) at moderate-to-high risk of stroke.
Official title: A Multicenter, RandomiZed, Active-ControLled Study to Evaluate the Safety and Tolerability of Two Blinded Doses of Abelacimab (MAA868) Compared With Open-Label Rivaroxaban in Patients With Atrial Fibrillation (AZALEA)
Key Details
Gender
All
Age Range
55 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1287
Start Date
2021-02-02
Completion Date
2028-12-29
Last Updated
2025-11-06
Healthy Volunteers
No
Conditions
Interventions
Abelacimab
Abelacimab provided as liquid in vial (150 mg/mL)
Rivaroxaban
Rivaroxaban 15 mg and 20 mg provided as commercially available film-coated tablets
Locations (92)
Anthos Investigative Site
Huntsville, Alabama, United States
Anthos Investigative Site
Mobile, Alabama, United States
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Stamford, Connecticut, United States
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Clearwater, Florida, United States
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Daytona Beach, Florida, United States
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Largo, Florida, United States
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Safety Harbor, Florida, United States
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Saint Augustine, Florida, United States
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Johns Creek, Georgia, United States
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Owensboro, Kentucky, United States
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Baltimore, Maryland, United States
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Salisbury, Maryland, United States
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Framingham, Massachusetts, United States
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Haverhill, Massachusetts, United States
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Lansing, Michigan, United States
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Sewell, New Jersey, United States
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Poughkeepsie, New York, United States
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Southampton, New York, United States
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Lenoir, North Carolina, United States
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Fargo, North Dakota, United States
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Oklahoma City, Oklahoma, United States
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Camp Hill, Pennsylvania, United States
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Kingsport, Tennessee, United States
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Kingwood, Texas, United States
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Odessa, Texas, United States
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Tomball, Texas, United States
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Falls Church, Virginia, United States
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Manassas, Virginia, United States
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Cambridge, Ontario, Canada
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Greater Sudbury, Ontario, Canada
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Oshawa, Ontario, Canada
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Greenfield Park, Quebec, Canada
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Montreal, Quebec, Canada
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Brandýs nad Labem, Central Bohemia, Czechia
Anthos Investigative Site
Poděbrady, Central Bohemia, Czechia
Anthos Investigative Site
Příbram, Central Bohemia, Czechia
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Slaný, Central Bohemia, Czechia
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Mariánské Lázně, KA, Czechia
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Trutnov, KR, Czechia
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Liberec, LB, Czechia
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Česká Lípa, LI, Czechia
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Liberec, LI, Czechia
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Pardubice, PA, Czechia
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Prague, PR, Czechia
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Prague, PR, Czechia
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Prague, PR, Czechia
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Kroměříž, ZL, Czechia
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Holešov, Zlín, Czechia
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Orosháza, BE, Hungary
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Baja, BK, Hungary
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Budapest, BP, Hungary
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Budapest, BP, Hungary
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Budapest, BU, Hungary
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Budapest, BU, Hungary
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Székesfehérvár, FE, Hungary
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Debrecen, HB, Hungary
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Kaposvár, SO, Hungary
Anthos Investigative Site (4002)
Nyíregyháza, SZ, Hungary
Anthos Investigative Site (4003)
Nyíregyháza, SZ, Hungary
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Balatonfüred, VE, Hungary
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Balatonfüred, VM, Hungary
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Gdynia, GDY, Poland
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Chrzanów, Lesser Poland Voivodeship, Poland
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Krakow, Lesser Poland Voivodeship, Poland
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Wroclaw, Lower Silesian Voivodeship, Poland
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Żarów, Lower Silesian Voivodeship, Poland
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Lublin, Lublin Voivodeship, Poland
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Zamość, Lubusz Voivodeship, Poland
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Płock, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Przemyśl, Podkarpackie Voivodeship, Poland
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Gdynia, Pomeranian Voivodeship, Poland
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Bielsko-Biala, Silesian Voivodeship, Poland
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Dąbrowa Górnicza, Silesian Voivodeship, Poland
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Ruda Śląska, Silesian Voivodeship, Poland
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Tychy, Silesian Voivodeship, Poland
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Elblag, Warmian-Masurian Voivodeship, Poland
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Lodz, Łódź Voivodeship, Poland
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Seogu, Busan, South Korea
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Seongnam-si, Gyeonggi-do, South Korea
Anthos Investigative Site
Seongnam-si, Gyeonggi-do, South Korea
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Seoul, Seoul, South Korea
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Seoul, Seoul, South Korea
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Seoul, Seoul, South Korea
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Taipei, HSZ, Taiwan
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Hualien City, HUA, Taiwan
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Yilan, ILA, Taiwan
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Kaohsiung City, KHH, Taiwan
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Taipei, TPE, Taiwan
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Taipei, TPE, Taiwan
Anthos Investigative Site
Tiachung, TXG, Taiwan