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Neural Biomarkers of Electroconvulsive Therapy Response
Sponsor: Northwell Health
Summary
In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry. Our study will recruit patients who are beginning treatment with bilateral electroconvulsive therapy (N=75). Our design will be longitudinal where patients will be followed up until their 8th week electroconvulsive therapy clinically. The primary measure of interest will be the slope of clinical change estimated with mixed effect modeling (see Approach). Secondary measures will be the cognitive performance change between baseline and the 8th week electroconvulsive therapy time point.
Official title: Neural Biomarkers of Electroconvulsive Therapy Response in Schizophrenia
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2020-04-01
Completion Date
2025-07-01
Last Updated
2024-10-01
Healthy Volunteers
No
Interventions
clinical and neuropsychological testing
Patients are monitored with Brief Psychiatric Rating Scale (BPRS) weekly and structural and functional MRI and MATRICS battery before and at the end of the course of the study
Locations (1)
The Zucker Hillside Hospital
Glen Oaks, New York, United States