Clinical Research Directory
Browse clinical research sites, groups, and studies.
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment
Sponsor: Imperial College London
Summary
A single centre, placebo controlled, blinded (participant, investigator, outcome assessor) trial to evaluate the effects of COX-2 inhibition with celecoxib on endothelial function in healthy male volunteers.
Official title: Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment (ASCENT)
Key Details
Gender
MALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
44
Start Date
2021-06-10
Completion Date
2022-01-24
Last Updated
2026-04-17
Healthy Volunteers
Yes
Conditions
Interventions
Celecoxib
Two 200 mg capsules per day (400 mg/day) for 7 days
Placebo
2 capsules/day for 7 days
L-arginine + placebo
L-arginine = Five capsules of 2 mg per day (10 mg/day) for 7 days Placebo = 2 capsules/day for 7 days
L-arginine + celecoxib
L-arginine = Five capsules of 2 mg per day (10 mg/day) Celecoxib = Two 200 mg capsules per day (400 mg/day) for 7 days
Locations (1)
Imperial College Clinical Research Facility
London, United Kingdom