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Quantitative Imaging of Brain Glymphatic Function in Humans
Sponsor: Vanderbilt University Medical Center
Summary
Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system exists in humans. If operative, this system may have central relevance to many vascular and fluid clearance disorders such as stroke, multiple sclerosis, Parkinson's disease, and Alzheimer's disease related dementia (ADRD): diseases which represent some of the most pressing healthcare challenges of the 21st century. Evaluating this possibility will require improved, robust imaging methods sensitive to lymphatic drainage dysfunction; as such, the goal of this work is to apply novel magnetic resonance imaging approaches, optimized already for evaluating lymphatic circulation in patients with peripheral lymphatic dysfunction, to quantify relationships between physiological hallmarks of ADRD and CNS lymphatic function in humans.
Key Details
Gender
All
Age Range
55 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2020-04-15
Completion Date
2026-12-31
Last Updated
2026-04-09
Healthy Volunteers
Yes
Conditions
Interventions
[11C]-PIB
\[11C\]-PIB is a PET radiotracer used to evaluate levels of Αβ burden.
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States