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AERIAL Trial: Antiplatelet Therapy in Heart Transplantation
Sponsor: Ottawa Heart Institute Research Corporation
Summary
Cardiac allograft vasculopathy is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. The research team is investigating whether early antiplatelet therapy post heart transplant can prevent the development of CAV. This study will determine the feasibility of a large multicenter randomized placebo-controlled trial to answer this question.
Official title: Early Initiation of Antiplatelet ThERapy In HeArt TranspLantation: AERIAL Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
135
Start Date
2021-06-28
Completion Date
2029-03
Last Updated
2025-04-03
Healthy Volunteers
No
Interventions
Placebo
patients randomized to placebo study group will be dispensed placebo capsules to be taken daily for the duration of the treatment
aspirin
patients randomized to aspirin study group will be dispensed aspirin capsules to be taken daily for the duration of the treatment
Clopidogrel
patients randomized to clopidogrel study group will be dispensed clopidogrel capsules to be taken daily for the duration of the treatment
Locations (3)
St.Pauls Hospital
Vancouver, British Columbia, Canada
University of Ottawa Heart Institute
Ottawa, Ontario, Canada
Toronto General Hospital UHN
Toronto, Ontario, Canada