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Genetic Studies of Strabismus, Nystagmus, and Associated Disorders
Sponsor: Boston Children's Hospital
Summary
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and/or whole genome sequencing will be used to identify genetic variants shared by family members with strabismus and to identify genetic causes of nystagmus.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2021-09-03
Completion Date
2030-12
Last Updated
2025-12-12
Healthy Volunteers
No
Conditions
Interventions
whole genome sequencing or whole exome sequencing
Whole genome sequencing or whole exome sequencing will be performed for all enrolled participants.
Locations (1)
Boston Children's Hospital
Boston, Massachusetts, United States