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RECRUITING
NCT04775134

Residual SARS-CoV-2 Presence in the Respiratory Tract and Lung Parenchyma (After SARS-CoV-2 Infection or COVID-19)

Sponsor: Universitaire Ziekenhuizen KU Leuven

View on ClinicalTrials.gov

Summary

The aim of this study is to confirm or rule out the residual presence and viability of SARS- CoV-2 in the respiratory tract and lung parenchyma of patients previously infected with SARS-CoV-2. Presence and viability of SARS-CoV-2 in lung tissue will be assessed with reverse transcriptase-polymerase chain reaction (PCR) and viral culture. The histological location of residual SARS-CoV-2 will be determined with fluorescence immunohistochemistry and single molecule fluorescence in situ hybridization, targeting viral proteins and RNA respectively.

Official title: Residual SARS-CoV-2 Presence in the Respiratory Tract and Lung Parenchyma

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

75

Start Date

2021-01-31

Completion Date

2025-12-31

Last Updated

2024-07-03

Healthy Volunteers

Not specified

Conditions

Interventions

DIAGNOSTIC_TEST

Lung biopsy

Biopsy of residuary material from a medically indicated pulmonary resection

Locations (1)

UZ Leuven

Leuven, Belgium