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Residual SARS-CoV-2 Presence in the Respiratory Tract and Lung Parenchyma (After SARS-CoV-2 Infection or COVID-19)
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
The aim of this study is to confirm or rule out the residual presence and viability of SARS- CoV-2 in the respiratory tract and lung parenchyma of patients previously infected with SARS-CoV-2. Presence and viability of SARS-CoV-2 in lung tissue will be assessed with reverse transcriptase-polymerase chain reaction (PCR) and viral culture. The histological location of residual SARS-CoV-2 will be determined with fluorescence immunohistochemistry and single molecule fluorescence in situ hybridization, targeting viral proteins and RNA respectively.
Official title: Residual SARS-CoV-2 Presence in the Respiratory Tract and Lung Parenchyma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
75
Start Date
2021-01-31
Completion Date
2025-12-31
Last Updated
2024-07-03
Healthy Volunteers
Not specified
Conditions
Interventions
Lung biopsy
Biopsy of residuary material from a medically indicated pulmonary resection
Locations (1)
UZ Leuven
Leuven, Belgium