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Genome Driven Primary Care Clinics - an RCT
Sponsor: Carmel Medical Center
Summary
A cluster randomized controlled study of 40 primary care clinics in Northern Israel (20 intervention clinics, 20 usual care clinics) to evaluate the value of introducing a precision medicine/genomic approach/paradigm on the clinical and economical outcomes of the clinics. Intervention includes 3 elements: 1. DNA extraction and evaluation (up to the level of WGS); 2. Feces sample for microbiome study, 3. Wearable devices for continuous monitoring of body functions. Expected number of participants is 100,000 in each arm. Results will be calculated for a clinic as a unit and not for individuals (each clinic to be compared to "twin" selected clinic).
Official title: Operating Community Primary Care Clinics Under Personalized Medicine Paradigm and Determining Differences in Health Outcomes Between Clinics With and Without Intervention.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200000
Start Date
2019-05-01
Completion Date
2029-12
Last Updated
2021-03-04
Healthy Volunteers
No
Interventions
Mutation arrays, NGS panels, GWAS, WES, WGS,
DNA extracted from peripheral blood as well as genetic analysis of bacteria from feces
wearable monitors
test various technologies of sensors to measure continuously various body functions and provide information to person and to physician
Locations (1)
Carmel Medical Center
Haifa, Israel