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Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
Sponsor: Johns Hopkins University
Summary
The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD). The overall objective of this study is to measure the changes in task-related neural activity related to symptoms of ADHD (measured by functional MRI) and brain glutamate levels (measured by magnetic resonance spectroscopy, MRS) after treatment with methylphenidate (MPH). This will be a double-blind crossover of methylphenidate and placebo in adults with ADHD. Participants will complete neuropsychological testing along with fMRI and MRS scans after a single dose of each treatment.
Key Details
Gender
All
Age Range
6 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2021-07-27
Completion Date
2029-04-30
Last Updated
2025-10-16
Healthy Volunteers
No
Conditions
Interventions
Methylphenidate
single dose of 10 mg or 15 mg
Placebo
Matching placebo
Locations (1)
Johns Hopkins School of Medicine
Baltimore, Maryland, United States