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Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
Sponsor: Vanderbilt University Medical Center
Summary
The iCAN trial is a pragmatic randomized controlled trial that aims to test the hypothesis that HFNC versus usual care oxygenation strategies applied immediately after initial extubation after cardiac surgery decreases the all-cause 48-hour reintubation rate (extubation failure within 48 hours of initial extubation).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3568
Start Date
2021-11-01
Completion Date
2026-03
Last Updated
2026-03-02
Healthy Volunteers
No
Interventions
Recommendation for high flow nasal cannula oxygen therapy order set
Participants will be assigned post extubation physician order set which recommends the administration of oxygen therapy via HFNC. HFNC is a heated and humidified system that allows prescribed fraction of inspired oxygen (FIO2) levels to be delivered at very high flow rates.
Provider choice standard care order set
Participants will receive order set with provider choice of standard care therapy.
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States