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COMPLETED
NCT04782869
NA

Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy

Sponsor: Assistance Publique Hopitaux De Marseille

View on ClinicalTrials.gov

Summary

This project aims to conduct a pilot study based on the targeting of the epileptogenic zone previously localized very precisely by stereoelectroencephalography (SEEG). SEEG is used as part of the pre-surgical assessment. It consists, thanks to the intracerebral implantation of electrodes in the brain of patients, to perform an intracerebral electrophysiological recording and thus to precisely explore the epileptogenic regions. In order to study the neuromodulatory and therapeutic effects of tDCS on epileptic brains, non-invasive techniques for measuring electrophysiological brain activity such as magnetoencephalography (MEG) and high-resolution electroencephalography (HR EEG) will be used. Finally, since epilepsy is considered to be a disorder of brain functional networks associated with disturbed brain connectivity, the effects of tDCS on cortical excitability by studying the variations in functional connectivity induced by stimulation will be studied.

Official title: Personalized Multichannel Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy: Evaluation of Therapeutic and Neurophysiological Effects

Key Details

Gender

All

Age Range

12 Years - Any

Study Type

INTERVENTIONAL

Enrollment

17

Start Date

2021-03-15

Completion Date

2024-02-21

Last Updated

2026-05-08

Healthy Volunteers

No

Conditions

Interventions

DEVICE

transcranial direct current stimulation

Patients will be treated using Starstim 8 device, a device allowing to perform transcranial direct current stimulation. The position of electrodes will be personalized based on the localization of the epileptogenic zone.

Locations (1)

Service d'Epileptologie et de Rythmologie Cérébrale

Marseille, France