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Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
Sponsor: AstraZeneca
Summary
The study will evaluate the efficacy and safety of trastuzumab deruxtecan (also known as T-DXd, DS-8201a), either alone or in combination with pertuzumab, in treating patients with Human epidermal growth factor receptor 2 (HER2)-positive breast cancer as a first line of treatment in the metastatic setting.
Official title: Phase III Study of Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive, First-line Metastatic Breast Cancer (DESTINY-Breast09)
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1157
Start Date
2021-04-26
Completion Date
2029-12-30
Last Updated
2026-02-20
Healthy Volunteers
No
Conditions
Interventions
Trastuzumab deruxtecan
Administered by intravenous infusion
Placebo
Administered by intravenous infusion
Taxane
Investigator's choice of docetaxel or paclitaxel administered by intravenous infusion
Pertuzumab
Administered by intravenous infusion
Trastuzumab
Administered by intravenous infusion
Locations (283)
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Tucson, Arizona, United States
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Springdale, Arkansas, United States
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Glendale, California, United States
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Glendale, California, United States
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Longmont, Colorado, United States
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Miami, Florida, United States
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Palm Bay, Florida, United States
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Plantation, Florida, United States
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Atlanta, Georgia, United States
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Louisville, Kentucky, United States
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Silver Spring, Maryland, United States
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Boston, Massachusetts, United States
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Detroit, Michigan, United States
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Jackson, Mississippi, United States
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Las Vegas, Nevada, United States
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Summit, New Jersey, United States
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New York, New York, United States
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Shirley, New York, United States
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York, Pennsylvania, United States
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Germantown, Tennessee, United States
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Dallas, Texas, United States
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Dallas, Texas, United States
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Denton, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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Shenandoah, Texas, United States
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Tyler, Texas, United States
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Norfolk, Virginia, United States
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Roanoke, Virginia, United States
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Tacoma, Washington, United States
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Buenos Aires, Argentina
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CABA, Argentina
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CABA, Argentina
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Caba, Argentina
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Capital Federal, Argentina
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Cipolletti, Argentina
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Ciudad de Buenos Aires, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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Rosario, Argentina
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Rosario, Argentina
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San Salvador de Jujuy, Argentina
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Brussels, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Edegem, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Liège, Belgium
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Namur, Belgium
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Florianópolis, Brazil
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Goiânia, Brazil
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Londrina, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Ribeirão Preto, Brazil
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São Paulo, Brazil
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Sorocaba, Brazil
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Vitória, Brazil
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Calgary, Alberta, Canada
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Halifax, Nova Scotia, Canada
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Barrie, Ontario, Canada
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Kitchener, Ontario, Canada
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Newmarket, Ontario, Canada
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North York, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Ste-Foy, Quebec, Canada
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Saskatoon, Saskatchewan, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Chongqing, China
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Dalian, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Kunming, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Nanning, China
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Qingdao, China
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Shanghai, China
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Shanghai, China
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Shenyang, China
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Shenzhen, China
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Tianjin, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Xi'an, China
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Yinchuan, China
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Zhengzhou, China
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Copenhagen O, Denmark
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Sønderborg, Denmark
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Vejle, Denmark
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Avignon, France
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Besançon, France
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Bordeaux, France
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Caen, France
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Le Mans, France
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Montpellier, France
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Montpellier, France
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Nice, France
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Paris, France
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Pierre-Bénite, France
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Rennes, France
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Saint-Cloud, France
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Saint-Herblain, France
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Toulouse, France
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Vandœuvre-lès-Nancy, France
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Berlin, Germany
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Dresden, Germany
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Erlangen, Germany
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Essen, Germany
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Frankfurt am Main, Germany
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Freiburg im Breisgau, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Leipzig, Germany
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Münster, Germany
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Paderborn, Germany
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Budapest, Hungary
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Budapest, Hungary
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Győr, Hungary
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Kecskemét, Hungary
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Nyíregyháza, Hungary
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Szolnok, Hungary
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Ahmedabad, India
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Bengaluru, India
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Calicut, India
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Gūrgaon, India
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Mysuru, India
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Nashik, India
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Nashik, India
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New Delhi, India
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New Delhi, India
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Haifa, Israel
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Jerusalem, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Tel Aviv, Israel
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Bergamo, Italy
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Candiolo, Italy
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Genova, Italy
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Livorno, Italy
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Milan, Italy
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Naples, Italy
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Padova, Italy
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Rozzano, Italy
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Udine, Italy
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Akashi-shi, Japan
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Aomori, Japan
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Bunkyō City, Japan
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Chiba, Japan
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Chūōku, Japan
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Fukushima, Japan
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Hidaka-shi, Japan
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Hiroshima, Japan
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Hiroshima, Japan
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Isehara-shi, Japan
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Kagoshima, Japan
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Kawasaki-shi, Japan
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Kobe, Japan
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Kōtoku, Japan
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Kurume-shi, Japan
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Kyoto, Japan
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Matsuyama, Japan
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Nagoya, Japan
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Nagoya, Japan
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Niigata, Japan
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Nishinomiya-shi, Japan
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Okayama, Japan
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Osaka, Japan
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Ota-shi, Japan
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Sapporo, Japan
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Sendai, Japan
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Shinagawa-ku, Japan
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Shizuoka, Japan
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Tsu, Japan
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Yokohama, Japan
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Baguio City, Philippines
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Iloilo City, Philippines
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Manila, Philippines
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San Juan City, Philippines
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Bucharest, Romania
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Floreşti, Romania
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Moscow, Russia
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Moscow, Russia
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Moscow, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Yaroslavl, Russia
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Dammam, Saudi Arabia
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Jeddah, Saudi Arabia
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Jeddah, Saudi Arabia
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Riyadh, Saudi Arabia
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Riyadh, Saudi Arabia
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Cape Town, South Africa
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Cape Town, South Africa
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George, South Africa
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Port Elizabeth, South Africa
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Pretoria, South Africa
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Rondebosch, South Africa
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Soweto, South Africa
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Daegu, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Alicante, Spain
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Barcelona, Spain
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Majadahonda, Spain
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Seville, Spain
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Gothenburg, Sweden
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Örebro, Sweden
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Stockholm, Sweden
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Uppsala, Sweden
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Vaxjo, Sweden
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan District, Taiwan
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Adana, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Cordaleo, Turkey (Türkiye)
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Malatya, Turkey (Türkiye)
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Samsun, Turkey (Türkiye)
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Buckhurst Hill, United Kingdom
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Edinburgh, United Kingdom
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Guildford, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Swansea, United Kingdom
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Taunton, United Kingdom