Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Sponsor: Vertex Pharmaceuticals Incorporated
Summary
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
Official title: A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus With Impaired Hypoglycemic Awareness and Severe Hypoglycemia
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
52
Start Date
2021-03-29
Completion Date
2030-06-30
Last Updated
2026-03-17
Healthy Volunteers
No
Interventions
VX-880
Infused into the hepatic portal vein.
Locations (29)
City of Hope
Duarte, California, United States
University of California San Francisco
San Francisco, California, United States
UHealth Diabetes Research Institute
Miami, Florida, United States
Northwestern Organ Transplant Center
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Johns Hopkins University
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center Montefiore
Pittsburgh, Pennsylvania, United States
Baylor Scott and White Research Institute
Dallas, Texas, United States
VCU Medical Center, Richmond
Richmond, Virginia, United States
University of Wisconsin
Madison, Wisconsin, United States
University of Alberta, Edmonton
Edmonton, Canada
McGill University Health Centre
Montreal, Canada
Toronto General Hospital (TGH)
Toronto, Canada
Vancouver General Hospital
Vancouver, Canada
CHU Lille
Lille, France
Centre de recherche en Biomédecine de Strasbourg
Strasbourg, France
Dresden Center for Islet Transplantation
Dresden, Germany
IRCCS Ospedale San Raffaele
Milan, Italy
Leiden University
Leiden, Netherlands
Oslo University Hospital
Oslo, Norway
King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology
Riyadh, Saudi Arabia
King Faisal Specialist Hospital & Research Centre - Riyadh - Endocrinology
Riyadh, Saudi Arabia
Hopiteaux Universitaires de Geneve
Geneva, Switzerland
Churchill Hospital
Headington, Oxford, United Kingdom
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
Cardiovascular, Metabolic Medicine and Sciences, King's College London
London, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom