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Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Sponsor: University of Colorado, Denver
Summary
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Key Details
Gender
All
Age Range
30 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2022-06-17
Completion Date
2027-02-15
Last Updated
2026-03-23
Healthy Volunteers
Yes
Conditions
Interventions
Cardiovascular exercise
15 weeks of cardiovascular exercise 3x/week for 50 minutes/session
Locations (2)
University of Colorado
Aurora, Colorado, United States
University of Virginia
Charlottesville, Virginia, United States