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Regional Phenotyping of CF and Non-CF Bronchiectasis
Sponsor: Children's Hospital Medical Center, Cincinnati
Summary
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.
Official title: Regional Phenotyping of Cystic Fibrosis Lung Disease and Non-CF Bronchiectasis
Key Details
Gender
All
Age Range
5 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2021-02-08
Completion Date
2027-03-31
Last Updated
2025-02-20
Healthy Volunteers
Yes
Conditions
Interventions
Xenon
Subjects will be scanned on a commercial 3T whole-body MRI scanner equipped with high-performance gradient systems. Natural isotopic abundance or isotopically-enriched xenon gas (\~86% 129Xe, Linde Inc.) will be used for all studies. Subjects will be positioned supine in the scanner with a 129Xe RF coil around their chests. Using conventional proton MRI and a breath-hold acquisition, "scout" images will be obtained to localize the subject for subsequent 129Xe acquisitions. 129Xe images will be acquired using the same breath-hold maneuver and a pulse sequence, covering the entire lung (acquisition time \<10 s, approximately 3-mm in-plane resolution, 15-mm slice thickness or less). Additional scans (sequences) may be performed. A maximum of 4 doses of 129Xe will be given throughout the study following the calibration dose.
Locations (1)
Penny New
Cincinnati, Ohio, United States