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RECRUITING
NCT04800393
NA

The Impact of Inhalation vs Total Intravenous Anesthesia on the Immune Status and Mortality in Patients Undergoing Breast Cancer Surgery: a Prospective Double-Blind Randomized Clinical Trial.

Sponsor: Moscow Clinical Scientific Center

View on ClinicalTrials.gov

Summary

Even decade ago it was believed that the choice method of anesthesia did not affect the course of the oncological process, but recent evidence has begun to emerge that inhalation anesthesia vs TIVA is associated with a higher number of adverse outcomes. Apparently, it makes sense to conduct mRCT in order to assess the effect of IA on immune system in patients operated on for breast cancer comprehensively. The results of that kind of RCT may finally give us an answer whether the choice of anesthesia affects the immune status of patients undergoing surgery for breast cancer. The evaluation of complications and long-term survival will allow to recommend to use or not to use IA for this type of surgery. Objective: The Impact of Inhalation vs Total Intravenous Anesthesia on the Immune Status and Mortality in Patients Undergoing Breast Cancer Surgery

Official title: The Impact of Inhalation vs Total Intravenous Anesthesia on the Immune Status and Mortality in Patients Undergoing Breast Cancer Surgery: a Prospective Double-Blind Randomized Clinical Trial (TeMP - Trial).

Key Details

Gender

FEMALE

Age Range

45 Years - 74 Years

Study Type

INTERVENTIONAL

Enrollment

130

Start Date

2022-03-29

Completion Date

2028-04-01

Last Updated

2023-04-26

Healthy Volunteers

No

Interventions

DRUG

Sevoflurane

induction of anesthesia with propofol, maintenance of anesthesia with sevoflurane during breast cancer surgery

DRUG

Propofol

propofol-based total intravenous anesthesia during breast cancer surgery

Locations (1)

Moscow Scientific Clinical Center

Moscow, Russia