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RECRUITING
NCT04804956

Mesorectal Microbiome and Metabolome as a Prognostic Factor in Patients With Rectal Cancer

Sponsor: University Hospital of Girona Dr. Josep Trueta

View on ClinicalTrials.gov

Summary

The equilibrium of intestinal microorganisms is essential for health an imbalance has been associated with an increased risk in the development of different pathologies; including colorectal cancer. Rectal cancer is the third most common neoplasm worldwide and the complete excision of the mesorectum is a major prognostic factor. The identification of microorganisms in the adipose tissue that surrounds the small intestine in inflammatory diseases, together with bacterial alterations found in colonic mucosa and feces in patients with rectal cancer in comparison with healthy individuals indicates that microbiome alteration plays an essential role in pathogenesis. The mesorectal microbiome in rectal cancer patients stills unknown and given its importance in the prognostic of the disease the goal of this study is to identify microbial profiles that allow predicting rectal cancer patients with a poor prognosis.

Official title: Mesorectal Microbiome and Metabolome as a Prognostic Factor in Patients With Rectal Cancer and Analysis of it's Applicability in Neoadjuvant Treatment

Key Details

Gender

All

Age Range

18 Years - 18 Years

Study Type

OBSERVATIONAL

Enrollment

100

Start Date

2021-04-01

Completion Date

2028-04-01

Last Updated

2026-06-10

Healthy Volunteers

Not specified

Conditions

Interventions

PROCEDURE

Stool sample

One stool sample will be taken at baseline for microbiota characterization

PROCEDURE

Rectal mucosa sample

Characterization of tissue microbiota before and after surgery.

PROCEDURE

Mesorectal adipose tissue sample

Characterization of tissue microbiota and dysfunction

PROCEDURE

Subcutaneous adipose tissue sample

Characterization of tissue microbiota and dysfunction

PROCEDURE

Visceral adipose tissue sample

Characterization of tissue microbiota and dysfunction

BEHAVIORAL

Dietary assessment

Dietary assessment will be taken at baseline

Locations (1)

Hospital Universitari Dr. Josep Trueta de Girona

Girona, Girona, Spain