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Mesorectal Microbiome and Metabolome as a Prognostic Factor in Patients With Rectal Cancer
Sponsor: University Hospital of Girona Dr. Josep Trueta
Summary
The equilibrium of intestinal microorganisms is essential for health an imbalance has been associated with an increased risk in the development of different pathologies; including colorectal cancer. Rectal cancer is the third most common neoplasm worldwide and the complete excision of the mesorectum is a major prognostic factor. The identification of microorganisms in the adipose tissue that surrounds the small intestine in inflammatory diseases, together with bacterial alterations found in colonic mucosa and feces in patients with rectal cancer in comparison with healthy individuals indicates that microbiome alteration plays an essential role in pathogenesis. The mesorectal microbiome in rectal cancer patients stills unknown and given its importance in the prognostic of the disease the goal of this study is to identify microbial profiles that allow predicting rectal cancer patients with a poor prognosis.
Official title: Mesorectal Microbiome and Metabolome as a Prognostic Factor in Patients With Rectal Cancer and Analysis of it's Applicability in Neoadjuvant Treatment
Key Details
Gender
All
Age Range
18 Years - 18 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2021-04-01
Completion Date
2028-04-01
Last Updated
2026-06-10
Healthy Volunteers
Not specified
Conditions
Interventions
Stool sample
One stool sample will be taken at baseline for microbiota characterization
Rectal mucosa sample
Characterization of tissue microbiota before and after surgery.
Mesorectal adipose tissue sample
Characterization of tissue microbiota and dysfunction
Subcutaneous adipose tissue sample
Characterization of tissue microbiota and dysfunction
Visceral adipose tissue sample
Characterization of tissue microbiota and dysfunction
Dietary assessment
Dietary assessment will be taken at baseline
Locations (1)
Hospital Universitari Dr. Josep Trueta de Girona
Girona, Girona, Spain