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COMPLETED
NCT04807023

Decompensation of Cirrhosis and Iron Metabolism

Sponsor: Rennes University Hospital

View on ClinicalTrials.gov

Summary

Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels. In line with the major role of the liver in iron homeostasis, links between iron metabolism and acute on chronic liver failure have been highlighted. Nevertheless, due to the difficulty of accurately assessing iron metabolism in this situation, therapeutic intervention on iron metabolism in this setting is currently not codified. A better understanding of these mechanisms is therefore essential, in particular by characterizing the impact of exposure to non-transferrin-bound iron in acute on chronic liver failure on short-term mortality. Overall, a better understanding of the physiopathological mechanisms of iron should allow to optimize the martial balance in this condition and also improve therapeutic approaches.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

98

Start Date

2021-09-08

Completion Date

2025-09-20

Last Updated

2026-06-12

Healthy Volunteers

No

Conditions

Interventions

BIOLOGICAL

blood sampling

blood sampling

Locations (1)

CHU Rennes

Rennes, France