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A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
The main goal of this prospective non-interventional exploratory monocentric study is to characterize the immune cell composition of bronchoalveolar lavage (BAL) fluid from cancer patients experiencing cancer therapy-induced pneumonitis on a single-cell scale. These mechanistic insights can directly lead to putative diagnostic biomarkers and therapeutic targets. A second highly clinically relevant hypothesis is that single-cell profiling of blood samples will reveal circulating biomarkers of ICB toxicity, making non-invasive diagnosis feasible.
Key Details
Gender
All
Age Range
18 Years - 120 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2020-02-01
Completion Date
2025-01-31
Last Updated
2024-07-01
Healthy Volunteers
No
Interventions
Immune checkpoint blockade
ICI, administered as standard-of-care treatment
Targeted therapy
TKI, administered as standard-of-care treatment
Radiotherapy
RT, administered as standard-of-care treatment
Locations (1)
Universitaire Ziekenhuizen Leuven
Leuven, Flemish Brabant, Belgium