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Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Sponsor: Wake Forest University Health Sciences
Summary
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Key Details
Gender
All
Age Range
25 Years - 59 Years
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2021-08-18
Completion Date
2027-05-31
Last Updated
2026-03-31
Healthy Volunteers
Yes
Interventions
Multimodal, multi-parametric MRI
The investigators will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes in vivo. Participants will be assessed three times over 2 years.
Immune and cytokine profiling
Blood samples will be collected for immune and cytokine profiling. Participants will be assessed three times over 2 years.
Neuropsychological testing
Participants will have neuropsychological testing three times over 2 years.
Locations (1)
Biotech Place
Winston-Salem, North Carolina, United States