Clinical Research Directory

Inclusion Criteria: 1. Signed Informed Consent 2. Clinically diagnosed as recurrent or drug-resistant trophoblastic tumor 3. After treatment with at least two or more multidrug chemotherapy regimens 4. Survival is expected to exceed 3 months 5. Age ≥18 years, age ≤75 years 6. Karnofsky score ≥60分，ECOG score ≤2分 7. No serious complications 8. Take effective contraceptives during treatment 9. Patients can be followed up as required 10. Blood test within 3 days: ANC≥1.5×109/L, PT ≥100×109/L, Hb≥90g/L, BIL ≤ 1.5 times of the high limit of normal value, ALT/ALST ≤ 1.5 times of the high limit of normal value, BUN and Cr≤ normal value 11. Coagulation function, thyroid function and myocardial enzyme in the normal range Exclusion Criteria: 1. Previously, he had received anti-PD-1, anti-PD-L1, bevacizumab and other drugs; 2. Within 2 weeks before the first administration, he had received anticancer Chinese patent medicine or immunomodulatory drugs; 3. Within 2 years before the first administration, he had received active autoimmune disease requiring systemic treatment; 4. Were receiving systemic glucocorticoid therapy or any other form of immunosuppressive therapy within 7 days prior to first administration; 5. Clinically uncontrollable pleural effusion/peritoneal effusion is present; 6. Allergic to PD-1 monoantibody, bevacizumab and other active ingredients or excipients； 7. Failure to fully recover from toxicity and/or complications； 8. History of HIV infection, untreated active hepatitis B, and active HCV infection subjects； 9. Live vaccine was administered within 30 days prior to the first dose； 10. Patients with serious or uncontrollable medical conditions who are not suitable for chemotherapy； 11. Participating in clinical trials of other drugs at the same time or 4 weeks before the first administration。