Clinical Research Directory
Browse clinical research sites, groups, and studies.
NAVA vs. CMV Crossover in Severe BPD
Sponsor: Children's Hospital of Philadelphia
Summary
This prospective, unblinded, pilot randomized cross-over trial of 2 modes of mechanical ventilation will compare measures of pulmonary mechanics, respiratory gas exchange, and patient comfort between conventional flow triggered mechanical ventilation and neurally adjusted ventilatory assist (NAVA) among 20 prematurely born infants and young children receiving invasive respiratory support for severe bronchopulmonary dysplasia (BPD).
Official title: Pilot Cross-Over Trial of Neurally Adjusted Ventilatory Assist (NAVA) and Conventional Flow Triggered Mechanical Ventilation (CMV) in Severe Bronchopulmonary Dysplasia (sBPD)
Key Details
Gender
All
Age Range
Any - 24 Months
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2021-09-13
Completion Date
2025-02-28
Last Updated
2026-05-20
Healthy Volunteers
No
Interventions
NAVA
NAVA mode of mechanical ventilation provide the trigger for a spontaneous breath from the diaphragmatic movement instead of diaphragm and allows the patient to control the dynamics of the breath generally set in CMV mode.
CMV
CMV mode of mechanical ventilation that provides a trigger for a spontaneous breath from the airway flow sensor with dynamics of the breath set as required by the mode
Locations (2)
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Rhode Island Hospital (Hasboro Children's Hospital)
Providence, Rhode Island, United States