Clinical Research Directory

These eligibility criteria only concern the adult cohort. INCLUSION CRITERIA : General inclusion criteria for all patients of all groups * Be 18 years or older * Get vaccinated against Covid-19 as part of the national vaccination campaign or having already received a first or second vaccine injection as part of the national vaccination campaign * Accept the conditions of participation corresponding to each sub-population * Commit to respecting the schedule of visits provided in the research protocol * Plan to reside in France for at least 2.5 years from inclusion date * Give their free, informed and written consent (at the latest on the day of inclusion and before any examination / samples) by signing the consent form * Be a member of or beneficiary of a social security scheme (State Medical Aid is not a social security scheme). General inclusion criteria for patients with a chronic condition of interest * Present at least one pathology listed * If the participant is participating in the in-depth immunology and virology study, they must have only one of the pathology of interest listed Inclusion criteria for control subjects • Be free from the chronic conditions of interest listed or other chronic conditions/treatment that may affect the immune response Inclusion criteria for control subjects free from chronic conditions of interest and with first injection with Astra-Zeneca vaccine AZD1222 and second injection with Pfizer ARNm vaccine BNT162b2 • Be vaccinated with a first injection with Astra-Zeneca vaccine AZD1222 and a second injection with Pfizer ARNm vaccine BNT162b2 NON INCLUSION CRITERIA : General non inclusion Criteria for all participants of all groups * Be under protective supervision (guardian or curatorship) * Being a pregnant or breastfeeding woman * Present a contraindication to Covid-19 vaccination : Have a known or suspected allergy to any component of the vaccine, Have had at-risk contact with a confirmed Covid-19 person in the last 7 days, Have presented clinical signs suggestive of Covid-19 in the last 7 days, Have an acute febrile episode on inclusion / vaccination, Have received a vaccine in the last 15 days ... * Have had a documented Covid-19 Infection (PCR or antigenic test) * Refuse that their Social Security number is collected for accessing the National Health Data System (NSDS)/Data Health Hub national health databases * For safety reasons, must agree to not enter in a vaccine clinical trial during the entire period of inclusion and follow-up of the research Specific non inclusion criteria for PLWHIV * Being infected with HIV-2 * Presenting another cause for immunosuppression (undergoing immunosuppressive treatment, biotherapy) * Presenting a non controlled opportunistic infection Specific non-inclusion criteria for control subjects * Have one or more of the chronic conditions of interest listed or affected by any other pathology or treatment that may affect the immune response (autoimmune/inflammatory pathology or immune deficiency not listed, liver failure, immunosuppressive therapy (like oral corticosteroids at \>= 10 mg/d Prednisone equivalent for more than 15 days) or radiotherapy within 6 months prior to inclusion or planned for the duration of the study) * Life expectancy of less than 2 years